Strains to go: interactions of the skin microbiome beyond its species.

Strains to go: interactions of the skin microbiome beyond its species.
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DOI:
10.1016/j.mib.2022.102222
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发表时间:
2022-12
影响因子:
5.4
通讯作者:
Oh, Julia
Oh, Julia
中科院分区:
生物学2区
文献类型:
--
作者:
Caldwell, Ryan;Zhou, Wei;Oh, Julia

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细菌、真菌、病毒,甚至是小型多细胞真核生物的非凡生物多样性栖息在人类皮肤上。基因组创新加速了在物种以及亚种或菌株水平上对这种生物多样性的表征,这进一步赋予了个体皮肤微生物组巨大的遗传多样性。反过来,这些进展预示着皮肤微生物组对皮肤免疫、屏障完整性、老化和其他皮肤生理过程的功能影响具有显著的物种和菌株特异性。未来在定义主要皮肤物种的菌株多样性、空间分布和代谢多样性方面的进展将是理解微生物组对皮肤生态系统的重要性以及设计利用或靶向皮肤微生物组的局部治疗的基础。
An extraordinary biodiversity of bacteria, fungi, viruses, and even small multicellular eukaryota inhabit the human skin. Genomic innovations have accelerated characterization of this biodiversity both at a species as well as the subspecies, or strain level, which further imparts a tremendous genetic diversity to an individual’s skin microbiome. In turn, these advances portend significant species- and strain-specificity in the skin microbiome’s functional impact on cutaneous immunity, barrier integrity, aging, and other skin physiologic processes. Future advances in defining strain diversity, spatial distribution, and metabolic diversity for major skin species will be foundational for understanding the microbiome’s essentiality to the skin ecosystem and for designing topical therapeutics that leverage or target the skin microbiome.
与痤疮相关的人皮肤微生物组中的痤疮丙酸杆菌菌株群体。
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