Sexual identity differences in biomarkers of tobacco exposure among women in a national sample.
Sexual identity differences in biomarkers of tobacco exposure among women in a national sample.
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DOI：
10.1016/j.canep.2021.101980
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发表时间：
2021-10
影响因子：
2.6
通讯作者：
McCabe SE
中科院分区：
文献类型：
--
作者：
Evans-Polce RJ;Smith DM;Veliz P;Boyd CJ;McCabe SE
与异性恋女性相比，性少数女性吸烟的风险一直在增加。尼古丁暴露的生物标志物和烟草毒物暴露的生物标志物均未通过性别鉴定进行检查。这项研究使用了烟草与健康人口评估（PATH）研究（2013-2014; n= 4，930）第1波生物标志物核心样本中女性的访谈和生物标志物数据。我们研究了性别认同与尼古丁暴露（用尿可替宁和TNE-2测量）和烟草特异性亚硝胺（用尿NNAL测量）的关系。使用多变量回归模型来检查完整生物标志物核心样本之间的这些关联，在过去30天的烟草使用者中，以及在控制烟草使用量和强度之前和之后的独家卷烟使用者中。在女性的完整生物标志物样本中，在调整烟草使用量和强度之前，双性恋女性的可替宁，TNE-2和NNAL水平显着高于异性恋女性。在专门建立的吸烟者，男同性恋/女同性恋妇女有显着较高的NNAL相比，异性恋妇女调整前的烟草数量和强度。在调整烟草使用量和强度后，没有发现性别认同的差异。这是第一项证明美国女性性别认同的烟草暴露生物标志物差异的研究，这具有重要的公共卫生意义，因为更多地暴露于尼古丁和烟草特有的亚硝胺与癌症风险密切相关。
Sexual minority women are consistently at increased risk for tobacco use compared to heterosexual women. Neither biomarkers of nicotine exposure nor biomarkers of tobacco toxicant exposure have been examined by sexual identity. This study used interview and biomarker data from women in the biomarker core sample of Wave 1 of the Population Assessment of Tobacco and Health (PATH) study (2013–2014; n=4,930). We examined associations of sexual identity with nicotine exposure (measured with urinary cotinine and TNE-2) and with tobacco-specific nitrosamines (measured with urinary NNAL). Multivariable regression modeling was used to examine these associations among the full biomarker core sample, among past 30-day tobacco users, and among exclusive established cigarette users before and after controlling for tobacco use quantity and intensity. In the full biomarker sample of women, prior to adjusting for tobacco use quantity and intensity, bisexual women had significantly higher cotinine, TNE-2, and NNAL levels compared to heterosexual women. Among exclusive established cigarette users, gay/lesbian women had significantly higher NNAL compared to heterosexual women prior to adjusting for tobacco quantity and intensity. No differences by sexual identity were found after adjusting for tobacco use quantity and intensity. This is the first study to demonstrate differences in biological markers of tobacco exposure by sexual identity among women in the U.S. This has important public health implications as greater exposure to both nicotine and to tobacco-specific nitrosamines are strongly linked to cancer risk.
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DOI：
10.1056/nejmsa1607538
发表时间：
2017-01-26
期刊：
The New England journal of medicine
影响因子：
--
作者：
Kasza KA;Ambrose BK;Conway KP;Borek N;Taylor K;Goniewicz ML;Cummings KM;Sharma E;Pearson JL;Green VR;Kaufman AR;Bansal-Travers M;Travers MJ;Kwan J;Tworek C;Cheng YC;Yang L;Pharris-Ciurej N;van Bemmel DM;Backinger CL;Compton WM;Hyland AJ
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发表时间：
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期刊：
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影响因子：
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作者：
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Hatsukami DK
DOI：
10.1158/1055-9965.epi-09-0874
发表时间：
2009-12
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
Goniewicz ML;Havel CM;Peng MW;Jacob P 3rd;Dempsey D;Yu L;Zielinska-Danch W;Koszowski B;Czogala J;Sobczak A;Benowitz NL
通讯作者：
Benowitz NL
DOI：
10.1176/appi.ajp.2020.20010005
发表时间：
2020-11-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Evans-Polce RJ;Kcomt L;Veliz PT;Boyd CJ;McCabe SE
通讯作者：
McCabe SE
影响因子：
5.2
作者：
Hyland, Andrew;Ambrose, Bridget K.;Compton, Wilson M.
通讯作者：
Compton, Wilson M.