Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks.
Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks.
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DOI：
10.1093/nar/gkn580
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发表时间：
2009-01
影响因子：
14.9
通讯作者：
Mattingly CJ
中科院分区：
文献类型：
--
作者：
Davis AP;Murphy CG;Saraceni-Richards CA;Rosenstein MC;Wiegers TC;Mattingly CJ
比较毒理基因组学数据库（CTD）是一个精心策划的数据库，旨在促进对环境化学品对人类健康影响的了解。CTD的生物学家从文献中手动策划化学-基因相互作用，化学-疾病关系和基因-疾病关系。这种策略允许整合数据以构建化学-基因-疾病网络。CTD在许多方面都是独一无二的：策展重点关注环境化学品;交互是手动策展的;交互是使用受控的词汇表和层次结构构建的;额外的基因属性（如基因本体论、分类学和KEGG途径）集成;数据可以从化学、基因或疾病的角度查看;结果和批量查询可以下载和保存;最重要的是，CTD既可以作为知识库（通过报告数据），也可以作为发现工具（通过产生新的推论）。从270个物种中收集了3900种化学物质和13300个基因之间的116000多个相互作用，并捕获了5900个基因-疾病和2500个化学物质-疾病的直接关系。通过整合这些数据，可以推断出350 000个基因-疾病关系和77 000个化学-疾病关系。这些丰富的化学基因疾病信息为理解环境化学物质对人类健康的影响提供了可检验的假设。CTD可在http://ctd.mdibl.org上免费获得。
The Comparative Toxicogenomics Database (CTD) is a curated database that promotes understanding about the effects of environmental chemicals on human health. Biocurators at CTD manually curate chemical–gene interactions, chemical–disease relationships and gene–disease relationships from the literature. This strategy allows data to be integrated to construct chemical–gene–disease networks. CTD is unique in numerous respects: curation focuses on environmental chemicals; interactions are manually curated; interactions are constructed using controlled vocabularies and hierarchies; additional gene attributes (such as Gene Ontology, taxonomy and KEGG pathways) are integrated; data can be viewed from the perspective of a chemical, gene or disease; results and batch queries can be downloaded and saved; and most importantly, CTD acts as both a knowledgebase (by reporting data) and a discovery tool (by generating novel inferences). Over 116 000 interactions between 3900 chemicals and 13 300 genes have been curated from 270 species, and 5900 gene–disease and 2500 chemical–disease direct relationships have been captured. By integrating these data, 350 000 gene–disease relationships and 77 000 chemical–disease relationships can be inferred. This wealth of chemical–gene–disease information yields testable hypotheses for understanding the effects of environmental chemicals on human health. CTD is freely available at http://ctd.mdibl.org.
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影响因子：
14.9
作者：
NCBI Resource Coordinators
通讯作者：
NCBI Resource Coordinators
Pfam：氏族、网络工具和服务。
影响因子：
14.9
作者：
Finn, Robert D.;Mistry, Jaina;Schuster-Bockler, Benjamin;Griffiths-Jones, Sam;Hollich, Volker;Lassmann, Timo;Moxon, Simon;Marshall, Mhairi;Khanna, Ajay;Durbin, Richard;Eddy, Sean R.;Sonnhammer, Erik L. L.;Bateman, Alex
通讯作者：
Bateman, Alex
影响因子：
14.9
作者：
Kanehisa M;Araki M;Goto S;Hattori M;Hirakawa M;Itoh M;Katayama T;Kawashima S;Okuda S;Tokimatsu T;Yamanishi Y
通讯作者：
Yamanishi Y
影响因子：
14.9
作者：
Mulder NJ;Apweiler R;Attwood TK;Bairoch A;Bateman A;Binns D;Bork P;Buillard V;Cerutti L;Copley R;Courcelle E;Das U;Daugherty L;Dibley M;Finn R;Fleischmann W;Gough J;Haft D;Hulo N;Hunter S;Kahn D;Kanapin A;Kejariwal A;Labarga A;Langendijk-Genevaux PS;Lonsdale D;Lopez R;Letunic I;Madera M;Maslen J;McAnulla C;McDowall J;Mistry J;Mitchell A;Nikolskaya AN;Orchard S;Orengo C;Petryszak R;Selengut JD;Sigrist CJ;Thomas PD;Valentin F;Wilson D;Wu CH;Yeats C
通讯作者：
Yeats C
影响因子：
2
作者：
Clavel, Jacqueline
通讯作者：
Clavel, Jacqueline