Global burden of human brucellosis: a systematic review of disease frequency.
Global burden of human brucellosis: a systematic review of disease frequency.
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DOI：
10.1371/journal.pntd.0001865
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发表时间：
2012
影响因子：
3.8
通讯作者：
Zinsstag J
中科院分区：
文献类型：
--
作者：
Dean AS;Crump L;Greter H;Schelling E;Zinsstag J
本报告介绍了世卫组织委托对1990-2010年期间发表的与人类布鲁氏菌病发病率有关的科学文献进行的系统综述。目的是确定高质量的疾病发病率数据，以补充现有的全球疾病负担知识，并最终有助于计算布鲁氏菌病的残疾调整生命年（DALY）估计值。检索了33个数据库，识别出2，385篇与人类布鲁氏菌病相关的文章。根据严格的筛选标准，选择了60项研究进行质量评估，其中只有29项具有足够的数据分析质量。只有北方非洲和中东、西欧、中美洲和南美洲、撒哈拉以南非洲和中亚地区15个国家的数据。一半的研究提供了发病率数据，其中6项是纵向前瞻性研究，一半提供了转换为发病率的血清阳性率数据。布鲁氏菌病的发病率在国家之间和国家内部差异很大。虽然不能排除研究偏见，但人口统计学，职业和社会经济因素可能发挥作用。国家或区域一级的汇总数据没有反映疾病动态的这些复杂性，因此，可能会忽略高危人群或地区。在许多布鲁氏菌病流行国家，卫生系统薄弱，被动获得的官方数据低估了真正的疾病负担。高质量的研究对于准确评估疾病负担至关重要，特别是在缺乏数据的东欧、亚太、中美洲和南美洲以及非洲。为研究人员提供正式的流行病学和统计学培训对于提高研究质量至关重要。采用涉及人类健康和兽医服务的综合性疾病监测方法，将有助于更好地了解动物-人类界面的疾病动态，并以更具成本效益的方式利用资源。布鲁氏菌病是一种细菌性疾病，通过食用受感染的未经巴氏消毒的动物奶或直接接触受感染的动物，特别是流产的胎儿传播给人类。这些堕胎造成的牲畜生产损失对个人和社区产生了重大的经济影响。受感染的人通常患有慢性、使人衰弱的疾病。这是人类布鲁氏菌病发病率的首次系统评价。使用严格的排除标准，确定了1990年1月至2010年6月期间发表的28篇包含高质量数据的科学文章。这些研究中有一半提供了发病率数据，另一半提供了血清阳性率数据，这些数据转换为发病率。只有北方非洲和中东、西欧、中美洲和南美洲、撒哈拉以南非洲和中亚地区15个国家的数据。布鲁氏菌病的发病率在国家之间和国家内部差异很大。人口、职业和社会经济因素可能在这些差异中发挥作用。在许多布鲁氏菌病流行国家，卫生系统薄弱，官方数据可能低估了真正的疾病负担。需要高质量的研究，特别是来自东欧、亚太、中美洲和南美洲以及非洲的研究。采用一种涉及人类健康和兽医服务的综合疾病监测方法，将使人们更好地了解这种疾病，并以更具成本效益的方式利用资源。
This report presents a systematic review of scientific literature published between 1990–2010 relating to the frequency of human brucellosis, commissioned by WHO. The objectives were to identify high quality disease incidence data to complement existing knowledge of the global disease burden and, ultimately, to contribute towards the calculation of a Disability-Adjusted Life Years (DALY) estimate for brucellosis. Thirty three databases were searched, identifying 2,385 articles relating to human brucellosis. Based on strict screening criteria, 60 studies were selected for quality assessment, of which only 29 were of sufficient quality for data analysis. Data were only available from 15 countries in the regions of Northern Africa and Middle East, Western Europe, Central and South America, Sub-Saharan Africa, and Central Asia. Half of the studies presented incidence data, six of which were longitudinal prospective studies, and half presented seroprevalence data which were converted to incidence rates. Brucellosis incidence varied widely between, and within, countries. Although study biases cannot be ruled out, demographic, occupational, and socioeconomic factors likely play a role. Aggregated data at national or regional levels do not capture these complexities of disease dynamics and, consequently, at-risk populations or areas may be overlooked. In many brucellosis-endemic countries, health systems are weak and passively-acquired official data underestimate the true disease burden. High quality research is essential for an accurate assessment of disease burden, particularly in Eastern Europe, the Asia-Pacific, Central and South America and Africa where data are lacking. Providing formal epidemiological and statistical training to researchers is essential for improving study quality. An integrated approach to disease surveillance involving both human health and veterinary services would allow a better understanding of disease dynamics at the animal-human interface, as well as a more cost-effective utilisation of resources. Brucellosis is a bacterial disease transmitted to humans by consumption of infected, unpasteurised animal milk or through direct contact with infected animals, particularly aborted foetuses. The livestock production losses resulting from these abortions have a major economic impact on individuals and communities. Infected people often suffer from a chronic, debilitating illness. This systematic review of the incidence of human brucellosis is the first ever conducted. Using strict exclusion criteria, 28 scientific articles published between January 1990–June 2010 which included high quality data were identified. Half of these studies presented incidence data and half presented seroprevalence data which were converted to incidence rates. Data were only available from 15 countries in the regions of Northern Africa and Middle East, Western Europe, Central and South America, Sub-Saharan Africa and Central Asia. Brucellosis incidence varied widely between and within countries. Demographic, occupational and socioeconomic factors may play a role in these differences. In many brucellosis-endemic countries, health systems are weak, and official data are likely to underestimate the true disease burden. High quality research is needed, particularly from Eastern Europe, the Asia-Pacific, Central and South America and Africa. An integrated approach to disease surveillance involving both human health and veterinary services would allow a better understanding of the disease, as well as a more cost-effective utilisation of resources.
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影响因子：
4.2
作者：
Avdikou, I;Maipa, V;Alamanos, Y
通讯作者：
Alamanos, Y
DOI：
10.1016/j.trstmh.2007.02.027
发表时间：
2007-07-01
影响因子：
2.2
作者：
Jennings, Gregory J.;Hajjeh, Rana A.;Mahoney, Francis J.
通讯作者：
Mahoney, Francis J.
影响因子：
6.4
作者：
Doyle, TJ;Bryan, RT
通讯作者：
Bryan, RT
影响因子：
--
作者：
Khorasgani, M. R.;Esmaeili, H.;Salehi, T. Z.
通讯作者：
Salehi, T. Z.
在21世纪治疗布鲁氏菌病的观点：ioannina的建议。
影响因子：
15.8
作者：
Ariza J;Bosilkovski M;Cascio A;Colmenero JD;Corbel MJ;Falagas ME;Memish ZA;Roushan MR;Rubinstein E;Sipsas NV;Solera J;Young EJ;Pappas G;International Society of Chemotherapy;Institute of Continuing Medical Education of Ioannina
通讯作者：
Institute of Continuing Medical Education of Ioannina