Children's exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric considerations.
Children's exposure to diagnostic medical radiation and cancer risk: epidemiologic and dosimetric considerations.
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DOI：
10.1007/s00247-008-1026-3
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发表时间：
2009-02
影响因子：
2.3
通讯作者：
Rajaraman P
中科院分区：
文献类型：
--
作者：
Linet MS;Kim KP;Rajaraman P
虽然大多数儿童癌症的病因在很大程度上是未知的，但流行病学研究一直发现怀孕期间暴露于医疗辐射与后代患儿童癌症的风险之间存在关联。生命早期诊断辐射照射与儿童癌症风险发生之间的关系尚不清楚。本综述总结了当前和历史的估计剂量为共同的诊断放射程序以及流行病学文献的作用，产妇产前，儿童的产后和父母的孕前诊断放射程序对随后的风险儿童恶性肿瘤的风险估计提出的因素，如出生年份的儿童，三个月和医疗适应症的程序，以及拍摄的电影数量。本文还讨论了流行病学研究中采用的方法来评估儿童癌症风险的局限性，流行病学研究报告的结果对临床实践的影响，以及研究结果对临床和公共卫生政策的影响。在理解和额外的研究需求的差距被确定。重要的研究优先事项包括全国性调查，以估计胎儿和儿童的辐射剂量从共同的诊断程序，和流行病学研究，以量化儿科和终身癌症的风险，从产前和幼儿暴露于诊断放射摄影，计算机断层扫描，和荧光引导程序。
While the etiology of most childhood cancers is largely unknown, epidemiologic studies have consistently found an association between exposure to medical radiation during pregnancy and risk of childhood cancer in offspring. The relation between early life diagnostic radiation exposure and occurrence of pediatric cancer risks is less clear. This review summarizes current and historical estimated doses for common diagnostic radiologic procedures as well as the epidemiologic literature on the role of maternal prenatal, children’s postnatal and parental preconception diagnostic radiologic procedures on subsequent risk of childhood malignancies Risk estimates are presented according to factors such as the year of birth of the child, trimester and medical indication for the procedure, and the number of films taken. The paper also discusses limitations of the methods employed in epidemiologic studies to assess pediatric cancer risks, the effects on clinical practice of the results reported from the epidemiologic studies, and clinical and public health policy implications of the findings. Gaps in understanding and additional research needs are identified. Important research priorities include nationwide surveys to estimate fetal and childhood radiation doses from common diagnostic procedures, and epidemiologic studies to quantify pediatric and lifetime cancer risks from prenatal and early childhood exposures to diagnostic radiography, computed tomography, and fluoroscopically-guided procedures.
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影响因子：
10.3
作者：
Cardis, E;Kesminiene, A;Williams, D
通讯作者：
Williams, D
影响因子：
8.8
作者：
Bithell, J F;Stewart, A M
通讯作者：
Stewart, A M
影响因子：
2.3
作者：
Chodick, Gabriel;Ronckers, Cecile;Shalev, Varda
通讯作者：
Shalev, Varda
影响因子：
2.2
作者：
Broder, Joshua;Fordham, Lynn Ansley;Warshauer, David M.
通讯作者：
Warshauer, David M.
DOI：
10.1016/0021-9681(65)90096-2
发表时间：
1965-01-01
期刊：
JOURNAL OF CHRONIC DISEASES
影响因子：
--
作者：
AGER, EA;SCHUMAN, LM;GULLEN, WH
通讯作者：
GULLEN, WH