Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies.
Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies.
复制标题
微形貌对植入生物材料骨整合的影响及其修饰策略
DOI：
10.3389/fbioe.2022.981062
复制
发表时间：
2022
影响因子：
5.7
通讯作者：
Gong, He
中科院分区：
文献类型：
--
作者：
Zhang, Yingying;Fan, Zhenmin;Xing, Yanghui;Jia, Shaowei;Mo, Zhongjun;Gong, He
骨科植入物广泛用于治疗损伤、感染、肿瘤和先天性疾病引起的骨缺损。然而，由于种植体与骨之间缺乏直接接触，骨整合不良和种植体失败仍然经常发生。为了提高种植体与宿主骨的生物整合，在种植材料的发展中，表面修饰是一个特别重要的问题。模拟天然骨的固有表面粗糙度和亲水性的植入物表面已被证明可以为成骨细胞提供促进组织再生和新骨形成的地形线索。越来越多的研究表明，细胞的附着、增殖和分化对这些种植体表面微形貌非常敏感。本文综述了表面修饰骨种植体的最新研究进展，重点介绍了表面微形貌如何调节体外成骨细胞分化和体内骨整合，以及表面修饰过程中的信号通路和类型。目的是系统地提供全面的参考信息，以更好地制造骨科植入物。
Orthopedic implants are widely used for the treatment of bone defects caused by injury, infection, tumor and congenital diseases. However, poor osseointegration and implant failures still occur frequently due to the lack of direct contact between the implant and the bone. In order to improve the biointegration of implants with the host bone, surface modification is of particular interest and requirement in the development of implant materials. Implant surfaces that mimic the inherent surface roughness and hydrophilicity of native bone have been shown to provide osteogenic cells with topographic cues to promote tissue regeneration and new bone formation. A growing number of studies have shown that cell attachment, proliferation and differentiation are sensitive to these implant surface microtopography. This review is to provide a summary of the latest science of surface modified bone implants, focusing on how surface microtopography modulates osteoblast differentiation in vitro and osseointegration in vivo, signaling pathways in the process and types of surface modifications. The aim is to systematically provide comprehensive reference information for better fabrication of orthopedic implants.
登录
查看更多内容
DOI：
10.1016/j.colsurfb.2019.02.037
发表时间：
2019-06-01
期刊：
Colloids and surfaces. B, Biointerfaces
影响因子：
--
作者：
Hasturk O;Ermis M;Demirci U;Hasirci N;Hasirci V
通讯作者：
Hasirci V
影响因子：
4.3
作者：
Hoornaert, Alain;Vidal, Luciano;Layrolle, Pierre
通讯作者：
Layrolle, Pierre
影响因子：
5.5
作者：
Chen, Cunte;Nie, Dingrui;Zeng, Chengwu
通讯作者：
Zeng, Chengwu
影响因子：
4.3
作者：
Donos, N.;Hamlet, S.;Ivanovski, S.
通讯作者：
Ivanovski, S.
影响因子：
4.6
作者：
Hao, L.;Lawrence, J.
通讯作者：
Lawrence, J.