Role for prazosin in reducing the development of rabbit intimal hyperplasia after endothelial denudation
Role for prazosin in reducing the development of rabbit intimal hyperplasia after endothelial denudation
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哌唑嗪抑制兔内皮剥脱后内膜增生的作用
DOI：
10.1002/bjs.1800760921
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发表时间：
1989
影响因子：
9.6
通讯作者：
N. O’higgins
中科院分区：
文献类型：
--
作者：
M. K. O'malley;E. McDermott;D. Mehigan;N. O’higgins
血管内膜增生是血管内皮细胞剥脱后的普遍反应，发生于各种血管手术后。在一定比例的病例中，平滑肌细胞的增殖可能导致血管狭窄。这些血管对去甲肾上腺素表现出更高的敏感性，而去甲肾上腺素可被α1肾上腺素能拮抗剂哌唑嗪降低。由于α1肾上腺素能受体和促进血管平滑肌细胞增殖的血小板衍生生长因子通过相同的代谢途径发挥作用，因此推测α1肾上腺素能受体阻滞剂可能抑制血管内膜增生的发展。使用Fogarty球囊导管对28只新西兰大白兔进行了主动脉内皮剥脱术。实验兔从手术之日起至处死前一直服用哌唑嗪。所有兔在内皮剥离后1周或4周处死。用X-Y数字化仪测量主动脉横断面的内膜增生，并以管腔缩小百分率为标准。治疗后1周和4周的管腔缩小率分别为0·75(1·8)%和9·7(3·1)%(P<；0·001)和4周(14·7(4·4)%和25·3(12·8)%，P<；0·05)。结论：哌唑嗪可显著减少血管内膜增生的发生。
Intimal hyperplasia is the universal response to endothelial denudation and occurs after a variety of vascular procedures. In a proportion of cases the smooth muscle cell proliferation may lead to stenosis of the blood vessels. These vessels exhibit increased sensitivity to noradrenaline that can be reduced by the α1‐adrenergic antagonist prazosin. Because the α1‐adrenergic receptor and platelet‐derived growth factor (which promotes vascular smooth muscle cell proliferation) act through the same metabolic pathway, it was postulated that α1‐adrenergic blockade might reduce the development of intimal hyperplasia. Twenty‐eight New Zealand White rabbits underwent endothelial denudation of the aorta using a Fogarty balloon catheter. Test rabbits were treated with prazosin from the day of operation until they were killed. All rabbits were killed either 1 or 4 weeks after endothelial denudation. Intimal hyperplasia in cross‐sections of the aorta was measured using an X — Y digitizer and was standardized in terms of percentage luminal reduction. Prazosintreated rabbits had significantly less luminal reduction at 1 week (0·75(1·8) versus 9·7(3·1) per cent, mean (s.d.), P <0·001) and at 4 weeks (14·7(4·4) versus 25·3(12·8) per cent, P <0·05) than control rabbits. It is concluded that prazosin caused a major reduction in the development of intimal hyperplasia.
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去甲肾上腺素引起的血管收缩在狗的内膜增生动脉中增加。
影响因子：
3.8
作者：
O'Malley,MK;Morris3rd,JJ;Makhoul,RG;Mikat,EM;Hagen,PO
通讯作者：
Hagen,PO
兔主动脉内膜增厚对去甲肾上腺素选择性超敏反应。
DOI：
10.1159/000158610
发表时间：
1985
期刊：
Blood vessels
影响因子：
--
作者：
Makhoul,RG;O'Malley,MK;Mikat,EM;Cole,CW;McCann,RL;Hagen,PO
通讯作者：
Hagen,PO
哌唑嗪可抑制内皮剥脱后血管收缩和对去甲肾上腺素敏感性的增加。
影响因子：
3.8
作者：
O'Malley,MK;Hagen,PO;Mikat,EM;Cole,CW;Radic,ZS;McCann,RL
通讯作者：
McCann,RL
DOI：
--
发表时间：
1982
期刊：
The Journal of thoracic and cardiovascular surgery
影响因子：
--
作者：
Pennock,JL;Oyer,PE;Reitz,BA;Jamieson,SW;Bieber,CP;Wallwork,J;Stinson,EB;Shumway,NE
通讯作者：
Shumway,NE
阿司匹林和双嘧达莫对去内皮化后血管 DNA 合成和内膜增生的作用。
DOI：
10.1016/0022-4804(86)90013-2
发表时间：
1986
期刊：
The Journal of surgical research
影响因子：
--
作者：
Radic,ZS;O'Malley,MK;Mikat,EM;Makhoul,RG;McCann,RL;Cole,CW;Hagen,PO
通讯作者：
Hagen,PO