Reaction Chemistry Generated by Nanosecond Pulsed Dielectric Barrier Discharge Treatment is Responsible for the Tumor Eradication in the B16 Melanoma Mouse Model.
Reaction Chemistry Generated by Nanosecond Pulsed Dielectric Barrier Discharge Treatment is Responsible for the Tumor Eradication in the B16 Melanoma Mouse Model.
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DOI：
10.1002/ppap.201500140
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Freeman TA
中科院分区：
文献类型：
--
作者：
Chernets N;Kurpad DS;Alexeev V;Rodrigues DB;Freeman TA
Melanoma is one of the most aggressive metastatic cancers with resistance to radiation and most chemotherapy agents. This study highlights an alternative treatment for melanoma based on nanosecond pulsed dielectric barrier discharge (nsP DBD). We show that a single nsP DBD treatment, directly applied to a 5 mm orthotopic mouse melanoma tumor, completely eradicates it 66% (n = 6; p ≤ 0.05) of the time. It was determined that reactive oxygen and nitrogen species produced by nsP DBD are the main cause of tumor eradication, while nsP electric field and heat generated by the discharge are not sufficient to kill the tumor. However, we do not discount that potential synergy between each plasma generated component (temperature, electric field and reactive species) can enhance the killing efficacy.
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3.2
作者：
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DOI：
10.1016/j.jphotobiol.2012.05.009
发表时间：
2012-10-03
影响因子：
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通讯作者：
Tedesco, Antonio C.