Malaria in Pregnancy Is a Predictor of Infant Haemoglobin Concentrations during the First Year of Life in Benin, West Africa.
Malaria in Pregnancy Is a Predictor of Infant Haemoglobin Concentrations during the First Year of Life in Benin, West Africa.
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DOI：
10.1371/journal.pone.0129510
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Cot M
中科院分区：
文献类型：
--
作者：
Accrombessi M;Ouédraogo S;Agbota GC;Gonzalez R;Massougbodji A;Menéndez C;Cot M
在非洲，贫血是一个日益被认识到的健康问题，特别是在婴儿和孕妇中。虽然已知疟疾是两组中贫血的主要危险因素，但母体因素，特别是妊娠期疟疾（MiP）对婴儿出生后最初几个月血红蛋白（Hb）浓度的影响仍不清楚。我们对1005名贝宁孕妇进行了从怀孕开始到分娩的随访。这些女性的前400个后代组成的子样本在出生时被选中，并一直跟踪到一岁。采用第一次临床产前检查（ANC）、第二次临床产前检查和分娩时的胎盘组织学和血液涂片来评估妊娠期间的疟疾。在出生、6个月、9个月和12个月时测量婴儿Hb浓度。一个混合的多层次模型被用来评估MiP和出生后12个月婴儿Hb变异之间的关系。胎盘疟疾（差异均值[dm] = - 2.8 g/L, 95% CI [-5.3, -0.3], P = 0.03）和分娩时母体外周寄生虫血症（dm = - 4.6 g/L, 95% CI [-7.9, -1.3], P = 0.007）是与出生后第一年婴儿Hb浓度显著相关的主要母体因素。母亲营养状况不佳和婴儿期疟疾感染也与婴儿Hb下降显著相关。应加强孕前和怀孕期间的抗疟疾控制和营养干预措施，以特别减少婴儿贫血的发病率，特别是在撒哈拉以南国家。
Anaemia is an increasingly recognized health problem in Africa, particularly in infants and pregnant women. Although malaria is known to be the main risk factor of anaemia in both groups, the consequences of maternal factors, particularly malaria in pregnancy (MiP), on infant haemoglobin (Hb) concentrations during the first months of life are still unclear. We followed-up a cohort of 1005 Beninese pregnant women from the beginning of pregnancy until delivery. A subsample composed of the first 400 offspring of these women were selected at birth and followed until the first year of life. Placental histology and blood smear at 1st clinical antenatal visit (ANC), 2nd ANC and delivery were used to assess malaria during pregnancy. Infant Hb concentrations were measured at birth, 6, 9 and 12 months of age. A mixed multi-level model was used to assess the association between MiP and infant Hb variations during the first 12 months of life. Placental malaria (difference mean [dm] = - 2.8 g/L, 95% CI [-5.3, -0.3], P = 0.03) and maternal peripheral parasitaemia at delivery (dm = - 4.6 g/L, 95% CI [-7.9, -1.3], P = 0.007) were the main maternal factors significantly associated with infant Hb concentrations during the first year of life. Poor maternal nutritional status and malaria infection during infancy were also significantly associated with a decrease in infant Hb. Antimalarial control and nutritional interventions before and during pregnancy should be reinforced to reduce specifically the incidence of infant anaemia, particularly in Sub-Saharan countries.
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影响因子：
3.4
作者：
Diouf, Ibrahima;Fievet, Nadine;Decloron, Philippe
通讯作者：
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影响因子：
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作者：
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DOI：
10.4269/ajtmh.2001.65.599
发表时间：
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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4.4
作者：
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通讯作者：
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影响因子：
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作者：
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