Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy.
Regulating Acidosis and Relieving Hypoxia by Platelet Membrane-Coated Nanoparticle for Enhancing Tumor Chemotherapy.
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DOI：
10.3389/fbioe.2022.885105
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发表时间：
2022
影响因子：
5.7
通讯作者：
Hu, Yong
中科院分区：
文献类型：
--
作者：
Luo, Xingyu;Cao, Jian;Yu, Jianming;Dai, Dongqing;Jiang, Wei;Feng, Yahui;Hu, Yong
肿瘤的酸中毒和缺氧仍然是肿瘤治疗的一大挑战。本文中，我们开发了Hb-LOX-DOX-ZIF 8 @血小板膜纳米颗粒（H-L-D-Z@PM NP）以解决该问题。乳酸氧化酶（LOX）能充分消耗肿瘤内的乳酸，有效地放大氧化应激。与此同时，血红蛋白（Hb）的目的是提供氧气，缓解缺氧，并提高LOX的催化活性。包覆后的PM赋予了这些纳米粒子主动的肿瘤靶向能力和良好的生物相容性。此外，沸石咪唑骨架-8（ZIF 8）的包封为纳米颗粒提供了酸响应能力。在化疗药物阿霉素（DOX）的协同作用下，H-L-D-Z@PM纳米粒显示出良好的抗肿瘤活性。本研究为通过调节酸中毒和缓解缺氧来加强肿瘤化疗提供了新的策略。
Acidosis and hypoxia of tumor remain a great challenge for cancer therapy. Herein, we developed Hb-LOX-DOX-ZIF8@platelet membrane nanoparticles (H-L-D-Z@PM NPs) to address this problem. Lactate oxidase (LOX) could deplete intratumoral lactate adequately and amplify oxidative stress efficiently. In the meantime, hemoglobin (Hb) was intended to deliver oxygen, relieve hypoxia, and boost the catalytic activity of LOX. The coated PM bestowed active tumor-targeting ability and good biocompatibility to these nanoparticles. Moreover, the encapsulation of zeolitic imidazolate framework-8 (ZIF8) offered the acid response capacity to nanoparticles. With the synergism of chemotherapy drug doxorubicin (DOX), these H-L-D-Z@PM NPs appeared to have excellent antitumor competence. Collectively, this study offered a new strategy for enhancing tumor chemotherapy by regulating acidosis and relieving hypoxia.
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