Dynamic Contrast-Enhanced Renal MRI at 7 Tesla: Preliminary Results
Dynamic Contrast-Enhanced Renal MRI at 7 Tesla: Preliminary Results
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7 特斯拉动态对比增强肾脏 MRI：初步结果
DOI：
10.1097/rli.0b013e31820e1467
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发表时间：
2011
影响因子：
6.7
通讯作者：
Lauenstein TC
中科院分区：
文献类型：
--
作者：
Umutlu L;Kraff O;Orzada S;Fischer A;Kinner S;Maderwald S;Antoch G;Quick HH;Forsting M;Ladd ME;Lauenstein TC
目的：随着超高场成像在神经和肌肉骨骼成像中的成功应用，科学研究的兴趣扩展到全身应用。本研究的目的是评估7特斯拉(T)动态增强肾脏磁共振成像(MRI)的可行性，并优化和实施专用检查方案。材料和方法：在7 T全身MR扫描仪上对10名健康受试者进行体内动态增强高场扫描。图像采集采用了适合于射频匀场的定制体形发射/接收减缩射频线圈。检查方案包括(1)稳态进动成像的真正快速成像，(2)T2加权增强脊柱回波成像，(3)T1加权(T1w)同相和反相成像，以及(4)脂肪饱和2D闪光序列。动态成像：静脉注射加多布曲尔，平扫及延迟20、70、120秒后行T1W三维闪光扫描。定性图像分析由2名资深放射科医生使用3分量表(1=差，2=中等，3=好)进行。测量所有序列肾皮质/髓质的信噪比和对比噪声比(CNR)。统计分析采用Wilcoxon等级检验。结果：所有检查均顺利完成，所有受试者均可耐受性良好，无任何副作用。T1w 2D闪光灯序列的整体图像质量最好，平均得分为2.57，其次是平衡阶段的对比度增强3D闪光灯序列(平均值为2.22)。T2加权Turbo脊柱回声成像提供的总体图像质量评分最低(1.30)，且受伪影影响最大。定量分析显示，动脉相3D闪光成像的皮质和髓质的CNR最高(CNR=12.2)，与所有其他序列相比，除同相和反相以及脂肪饱和的2D闪光序列外，其他序列差异均有统计学意义。反之，平衡期闪光成像的CNR评分最低，仅为3.6分。结论：本可行性研究揭示了超高场磁共振腹部成像的诊断潜力和目前的局限性。我们的初步结果证明了专用动态对比剂7T肾脏MRI的潜力，以及进一步优化成像序列和RF线圈概念的必要性。
Objective:With the successful implementation of ultra-high-field imaging in neuro-and musculoskeletal imaging, the interest of scientific research expanded toward whole-body applications. The aim of this study was to assess the feasibility of dynamic contrast-enhanced renal magnetic resonance imaging (MRI) at 7 Tesla (T), with optimization and implementation of a dedicated examination protocol.Material and Methods:In vivo dynamic contrast-enhanced high-field examinations were obtained in 10 healthy subjects on a 7 T whole-body MR scanner. A custom-built body transmit/receive reduced radiofrequency (RF) coil suitable for RF shimming was used for image acquisition. The examination protocol included (1) true fast imaging with steady-state precession imaging,(2) T2-weighted turbo spine echo imaging,(3) T1-weighted (T1w) in-and opposed-phase imaging, and (4) a fat-saturated 2D FLASH sequence. For dynamic imaging, gadobutrol was injected intravenously and T1w 3D FLASH images were obtained precontrast and at 20, 70, and 120 seconds delay. Qualitative image analysis was performed by 2 senior radiologists using a 3-point scale (1= poor, 2= moderate, 3= good quality). Signal-to-noise ratio and contrast-to-noise ratio (CNR) of the renal cortex/medulla were measured for all sequences. For statistical analysis, a Wilcoxon Rank Test was used.Results:All examinations were performed successfully and were well tolerated by all subjects without any side effects. Best overall image quality was rated for the T1w 2D FLASH sequence with an average score of 2.57, followed by the contrast-enhanced 3D FLASH sequence in the equilibrium phase (mean, 2.22). T2-weighted turbo spine echo imaging provided the weakest overall image quality score (1.30) and was most impaired by artifacts. Quantitative analysis showed highest CNR between cortex and medulla for arterial phase 3D FLASH imaging (CNR= 12.2), providing a statistically significant difference to all other sequences, except for the in-and opposed-phase and the fat-saturated 2D FLASH sequence. Conversely, equilibrium phase FLASH imaging yielded the weakest CNR score of 3.6.Conclusion:This feasibility study reveals the diagnostic potential and current constraints of ultra-high-field abdominal MRI. Our initial results demonstrate the potential of dedicated dynamic-contrast 7 T renal MRI and the need for further optimization of imaging sequences and RF coil concepts.
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影响因子：
2.5
作者：
Ibrahim, TS;Lee, R;Robitaille, PML
通讯作者：
Robitaille, PML
影响因子：
4.8
作者：
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通讯作者：
Lauenstein, Thomas C.
影响因子：
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作者：
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影响因子：
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作者：
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MR 结肠成像：1.5T 与 3T。
影响因子：
1.6
作者：
T. Lauenstein;B. Saar;Diego R. Martín
通讯作者：
Diego R. Martín