Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a 'natural experiment' allowing analysis of data from the prior two decades.
Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a 'natural experiment' allowing analysis of data from the prior two decades.
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DOI：
10.1136/bmjgh-2020-003075
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发表时间：
2020-09
影响因子：
8.1
通讯作者：
Dunne CP
中科院分区：
文献类型：
--
作者：
Philip RK;Purtill H;Reidy E;Daly M;Imcha M;McGrath D;O'Connell NH;Dunne CP
极低出生体重（VLBW）和极低出生体重（ELBW）婴儿的出生病因是多种多样的，预防策略仍然难以捉摸。爱尔兰为应对SARS-CoV-2病毒（COVID-19）大流行而实施的社会环境措施代表了全国封锁，并可能影响了孕妇和未出生婴儿的健康和福祉。分析了爱尔兰一个指定卫生区20年来极低出生体重和极低出生体重婴儿的区域趋势。进行Poisson回归和率比分析，95% CI。覆盖2020年大部分封城期的区域数据与区域及国家历史数据以及2020年国家预测数据进行了比较。泊松回归分析发现，2001年至2019年1月至4月，每1000例活产的区域历史VLBW率为8.18（95% CI 7.21至9.29）。在2020年1月至4月期间，观察到极低出生体重率异常低，每1000例活产仅为2. 17例，反映率比为3. 77（95% CI 1. 21至11. 75），p= 0. 022，与过去二十年同期相比，2020年前4个月的极低出生体重率下降了73%。没有ELBW婴儿入住区域新生儿重症监护室。预计2020年爱尔兰全国极低出生体重率将从历史上的500-600范围降至每60 000例分娩约400例。爱尔兰的极低出生体重和极低出生体重婴儿的地区出生率出现前所未有的下降，与COVID-19封锁相吻合。这一独特时间趋势的潜在决定因素可能在于COVID-19封锁对社会环境的总体影响。我们的研究结果，如果反映在其他地区已采取封锁，证明有可能评估这些牵连的行为和社会环境的修改器，以积极影响VLBW和ELBW率全球。
Aetiology of births involving very low birthweight (VLBW) and extremely low birthweight (ELBW) infants is heterogeneous and preventive strategies remain elusive. Socioenvironmental measures implemented as Ireland’s response to the SARS-CoV-2 virus (COVID-19) pandemic represented a national lockdown, and have possibly influenced the health and well-being of pregnant women and unborn infants. Regional trends of VLBW and ELBW infants in one designated health area of Ireland over two decades were analysed. Poisson regression and rate ratio analyses with 95% CI were conducted. Regional data covering most of the lockdown period of 2020 were compared with historical regional and national data and forecasted national figures for 2020. Poisson regression analysis found that the regional historical VLBW rate per 1000 live births for January to April, 2001–2019 was 8.18 (95% CI 7.21 to 9.29). During January to April 2020, an unusually low VLBW rate of just 2.17 per 1000 live births was observed, reflecting a rate ratio of 3.77 (95% CI 1.21 to 11.75), p=0.022, representing a 73% reduction of VLBW during the first 4 months of 2020 compared with same period for the preceding two decades. There were no ELBW infants admitted to the regional neonatal intensive care unit. National Irish VLBW rate for 2020 is forecasted to be reduced to approximate 400 per 60 000 births compared with the historical 500–600 range. An unprecedented reduction in regional births of VLBW and ELBW infants was observed in Ireland coinciding with the COVID-19 lockdown. Potential determinants of this unique temporal trend possibly reside in the summative socioenvironmental impact of the COVID-19 lockdown. Our findings, if mirrored in other regions that have adopted a lockdown, demonstrate the potential to evaluate these implicated behavioural and socioenvironmental modifiers to positively influence VLBW and ELBW rates globally.
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影响因子：
168.9
作者：
Liu, Li;Oza, Shefali;Hogan, Dan;Chu, Yue;Perin, Jamie;Zhu, Jun;Lawn, Joy E.;Cousens, Simon;Mathers, Colin;Black, Robert E.
通讯作者：
Black, Robert E.
DOI：
10.1016/s2214-109x(18)30451-0
发表时间：
2019-01
期刊：
The Lancet. Global health
影响因子：
--
作者：
Chawanpaiboon S;Vogel JP;Moller AB;Lumbiganon P;Petzold M;Hogan D;Landoulsi S;Jampathong N;Kongwattanakul K;Laopaiboon M;Lewis C;Rattanakanokchai S;Teng DN;Thinkhamrop J;Watananirun K;Zhang J;Zhou W;Gülmezoglu AM
通讯作者：
Gülmezoglu AM
DOI：
10.2471/blt.08.062554
发表时间：
2010-01-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Beck, Stacy;Wojdyla, Daniel;Look, Paul FA Van
通讯作者：
Look, Paul FA Van
影响因子：
2.1
作者：
Govindaswami, Balaji;Jegatheesan, Priya;Narasimhan, Sudha Rani
通讯作者：
Narasimhan, Sudha Rani
影响因子：
3.7
作者：
Nassar, Natasha;Schiff, Michal;Roberts, Christine L
通讯作者：
Roberts, Christine L