The ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women.
The ovariectomized rat as a model for studying alveolar bone loss in postmenopausal women.
复制标题
卵巢切除大鼠是研究绝经后妇女肺泡骨质流失的模型。
DOI：
10.1155/2015/635023
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发表时间：
2015
影响因子：
--
通讯作者：
Ward WE
中科院分区：
文献类型：
--
作者：
Johnston BD;Ward WE
在绝经后妇女中，髋部和脊柱的骨密度降低与牙齿脱落的风险增加有关，可能是由于牙槽骨的损失。反过来，天然牙齿较少可能导致食物选择受损，导致饮食不良，从而导致慢性疾病风险。牙槽骨保存、牙齿保留、更好的营养状况和降低患慢性疾病的风险之间的紧密联系始于绝经后骨质流失的减轻。卵巢切除大鼠是一种广泛使用的临床前模型，用于研究绝经后骨质流失，模拟髋关节和脊柱中骨组织的退化，也可用于研究牙槽骨中的矿物质和结构变化，以开发旨在保持牙齿的药物和/或饮食策略。这篇综述讨论了在卵巢切除大鼠模型中研究下颌骨健康和牙槽骨的关键发现。考虑到最大限度地发挥这种模式的好处也包括在内。这些包括所使用的测量技术，卵巢切除术时的年龄，卵巢切除术后研究大鼠的持续时间和习惯性饮食。
In postmenopausal women, reduced bone mineral density at the hip and spine is associated with an increased risk of tooth loss, possibly due to a loss of alveolar bone. In turn, having fewer natural teeth may lead to compromised food choices resulting in a poor diet that can contribute to chronic disease risk. The tight link between alveolar bone preservation, tooth retention, better nutritional status, and reduced risk of developing a chronic disease begins with the mitigation of postmenopausal bone loss. The ovariectomized rat, a widely used preclinical model for studying postmenopausal bone loss that mimics deterioration of bone tissue in the hip and spine, can also be used to study mineral and structural changes in alveolar bone to develop drug and/or dietary strategies aimed at tooth retention. This review discusses key findings from studies investigating mandible health and alveolar bone in the ovariectomized rat model. Considerations to maximize the benefits of this model are also included. These include the measurement techniques used, the age at ovariectomy, the duration that a rat is studied after ovariectomy and habitual diet consumed.
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影响因子：
3.3
作者：
Jiang, Gui-Zhen;Matsumoto, Hiroko;Fujii, Akira
通讯作者：
Fujii, Akira
影响因子：
2.1
作者：
Brennan, D. S.;Singh, K. A.;Spencer, A. J.
通讯作者：
Spencer, A. J.
影响因子：
--
作者：
Civitelli, R;Pilgram, TK;Hildebolt, CF
通讯作者：
Hildebolt, CF
影响因子：
3
作者：
Kawamoto, S;Ejiri, S;Ozawa, H
通讯作者：
Ozawa, H
影响因子：
2.3
作者：
Ervin, R. Bethene;Dye, Bruce A.
通讯作者：
Dye, Bruce A.