The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.
The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family.
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DOI：
10.1186/1471-2148-5-31
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发表时间：
2005-05-13
影响因子：
3.4
通讯作者：
Boot-Handford RP
中科院分区：
文献类型：
--
作者：
Ewan R;Huxley-Jones J;Mould AP;Humphries MJ;Robertson DL;Boot-Handford RP
整合素是一个功能重要的后生动物细胞表面粘附受体家族。受体是由α链和β链组成的二聚体。脊椎动物基因组编码一组扩大的整合素α和β链相比，原口类，如果蝇或线虫。发表的基因组的基础脊索动物，玻璃海鞘，提供了一个独特的机会，以进一步了解如何以及何时在脊椎动物中发现的扩展整合素超基因家族进化。玻璃海鞘基因组编码11个α链和5个β链基因，这些基因与它们的脊椎动物同源物高度同源。八条α链含有A结构域，缺乏胶原结合脊椎动物α链中存在的短α螺旋区。系统发育分析表明，八个A-结构域含有α链集群形成海鞘特有的分支，这是相关的，但不同，脊椎动物的A-结构域分支。两条玻璃海鞘α链聚集在层粘连蛋白结合进化枝中，其余链聚集在结合RGD三肽序列的进化枝中。在5条玻璃海鞘β链中，3条形成海鞘特异性进化枝，1条聚集在脊椎动物β1进化枝中，剩余的玻璃海鞘链是脊椎动物β4链的直向同源物。玻璃海鞘的整联蛋白基因库提供了新的见解，这些受体的基本设置在脊椎动物进化的开始。海鞘和脊椎动物α链A结构域分支起源于共同的前体，但在每个谱系中分别辐射。似乎在海鞘分化后，脊索动物谱系中出现了胶原结合能力的获得。
Integrins are a functionally significant family of metazoan cell surface adhesion receptors. The receptors are dimers composed of an alpha and a beta chain. Vertebrate genomes encode an expanded set of integrin alpha and beta chains in comparison with protostomes such as drosophila or the nematode worm. The publication of the genome of a basal chordate, Ciona intestinalis, provides a unique opportunity to gain further insight into how and when the expanded integrin supergene family found in vertebrates evolved. The Ciona genome encodes eleven α and five β chain genes that are highly homologous to their vertebrate homologues. Eight of the α chains contain an A-domain that lacks the short alpha helical region present in the collagen-binding vertebrate alpha chains. Phylogenetic analyses indicate the eight A-domain containing α chains cluster to form an ascidian-specific clade that is related to but, distinct from, the vertebrate A-domain clade. Two Ciona α chains cluster in laminin-binding clade and the remaining chain clusters in the clade that binds the RGD tripeptide sequence. Of the five Ciona β chains, three form an ascidian-specific clade, one clusters in the vertebrate β1 clade and the remaining Ciona chain is the orthologue of the vertebrate β4 chain. The Ciona repertoire of integrin genes provides new insight into the basic set of these receptors available at the beginning of vertebrate evolution. The ascidian and vertebrate α chain A-domain clades originated from a common precursor but radiated separately in each lineage. It would appear that the acquisition of collagen binding capabilities occurred in the chordate lineage after the divergence of ascidians.
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影响因子：
30.8
作者：
McLysaght, A;Hokamp, K;Wolfe, KH
通讯作者：
Wolfe, KH
影响因子：
3.5
作者：
Tuckwell, DS;Humphries, MJ
通讯作者：
Humphries, MJ
DOI：
10.1073/pnas.94.17.9182
发表时间：
1997-08-19
影响因子：
11.1
作者：
Brower, DL;Brower, SM;Ball, EE
通讯作者：
Ball, EE
影响因子：
2.4
作者：
Sasakura, Y;Shoguchi, E;Satoh, N
通讯作者：
Satoh, N
影响因子：
56.9
作者：
Dehal, P;Satou, Y;Rokhsar, DS
通讯作者：
Rokhsar, DS