Addiction vulnerability trait impacts complex movement control: Evidence from sign-trackers.
Addiction vulnerability trait impacts complex movement control: Evidence from sign-trackers.
复制标题
成瘾脆弱性特质会影响复杂的运动控制：签名者的证据。
DOI：
10.1016/j.bbr.2018.04.045
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发表时间：
2018-09-17
影响因子：
2.7
通讯作者：
Sarter M
中科院分区：
文献类型：
--
作者：
Kucinski A;Lustig C;Sarter M
认知动机脆弱性特征与物质成瘾和复发的风险增加有关。大鼠的信号追踪（ST）行为与注意力控制不良相关，由无反应的基底前脑胆碱能系统介导，并增加物质成瘾/复发的风险。另一篇文献将注意力控制不良和胆碱能损失与帕金森病跌倒风险增加联系起来。在这里，我们测试的假设，相对较差的注意力控制的ST延伸到复杂的运动控制和福尔斯的倾向。ST被发现下降更经常比目标跟踪器（GT），而穿越一个直旋转杆，类似于人类的秋天，当征税的次要任务。此外，ST下降更频繁，而遍历旋转之字形杆。GT表现出更少的福尔斯，从这个杆避免进入旋转之字形部分时，在或向旋转，一个困难的横向状态。目标跟踪大鼠接近危险的运动情况下使用的策略指示上级自上而下的控制。这些结果表明，对手的认知胆碱能特性的影响延伸到复杂的运动控制，在认知运动接口的障碍可能是共病与成瘾的脆弱性。信号跟踪指数内表型，可能会增加风险的广泛的神经行为障碍。
Cognitive-motivational vulnerability traits are associated with increased risk for substance addiction and relapse. Sign-tracking (ST) behavior in rats is associated with poor attentional control, mediated by an unresponsive basal forebrain cholinergic system, and an increased risk for substance addiction/relapse. A separate literature links poor attentional control and cholinergic losses to increased fall risk in Parkinson’s disease. Here we tested the hypothesis that the relatively inferior attentional control of STs extends to complex movement control and a propensity for falls. STs were found to fall more often than goal-trackers (GTs) while traversing a straight rotating rod and, similar to human fallers, when taxed by a secondary task. Furthermore, STs fell more often while traversing a rotating zig-zag rod. GTs exhibited fewer falls from this rod by avoiding entry to the rotating zig-zag sections when in, or rotating toward, a difficult traversal state. Goal-tracking rats approached risky movement situations using strategies indicative of superior top-down control. These results suggest that the impact of opponent cognitive-cholinergic traits extends to complex movement control, and that impairments in the cognitive-motor interface are likely to be comorbid with addiction vulnerability. Sign-tracking indexes an endophenotype that may increase the risk for a wide range of neurobehavioral disorders.
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影响因子：
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