Beringian standstill and spread of Native American founders.
Beringian standstill and spread of Native American founders.
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DOI：
10.1371/journal.pone.0000829
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发表时间：
2007-09-05
期刊：
影响因子：
3.7
通讯作者：
Malhi RS
中科院分区：
文献类型：
--
作者：
Tamm E;Kivisild T;Reidla M;Metspalu M;Smith DG;Mulligan CJ;Bravi CM;Rickards O;Martinez-Labarga C;Khusnutdinova EK;Fedorova SA;Golubenko MV;Stepanov VA;Gubina MA;Zhadanov SI;Ossipova LP;Damba L;Voevoda MI;Dipierri JE;Villems R;Malhi RS
美洲原住民起源于少数可能通过白令加到达美洲的亚洲创始人。然而，关于美洲最初殖民的其他细节仍然不清楚。为了研究美洲的开创性阶段，我们分析了来自美洲和亚洲的623个完整的mtDNA，包括20个来自美洲的新的完整mtDNA和7个来自亚洲的mtDNA。该序列数据用于指导来自20个美国人和26个亚洲人群体的高分辨率基因分型。在这里，我们描述了更多的遗传多样性的创始人人口比以前报道的。新解决的系统发育结构表明，美洲原住民的祖先在到达白令加时暂停了，在此期间，新世界创始人谱系与他们的亚洲姐妹分支不同。这一运动的停顿之后是一个迅速向南迁移，分布的创始人类型一直到南美洲。这些数据还表明，西伯利亚和北美北极地区之间的双向基因流动更为近期。
Native Americans derive from a small number of Asian founders who likely arrived to the Americas via Beringia. However, additional details about the intial colonization of the Americas remain unclear. To investigate the pioneering phase in the Americas we analyzed a total of 623 complete mtDNAs from the Americas and Asia, including 20 new complete mtDNAs from the Americas and seven from Asia. This sequence data was used to direct high-resolution genotyping from 20 American and 26 Asian populations. Here we describe more genetic diversity within the founder population than was previously reported. The newly resolved phylogenetic structure suggests that ancestors of Native Americans paused when they reached Beringia, during which time New World founder lineages differentiated from their Asian sister-clades. This pause in movement was followed by a swift migration southward that distributed the founder types all the way to South America. The data also suggest more recent bi-directional gene flow between Siberia and the North American Arctic.
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影响因子：
9.8
作者：
Malhi, RS;Eshleman, JA;Smith, DG
通讯作者：
Smith, DG
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1.9
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Malyarchuk, BA;Rogozin, IB
通讯作者：
Rogozin, IB
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Brown, MD;Hosseini, SH;Wallace, DC
通讯作者：
Wallace, DC
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Kaestle, FA;Smith, DG
通讯作者：
Smith, DG
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Maca-Meyer N;González AM;Larruga JM;Flores C;Cabrera VM
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Cabrera VM