Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases.
Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases.
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DOI：
10.3389/fimmu.2020.625833
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发表时间：
2020
影响因子：
7.3
通讯作者：
Kawai T
中科院分区：
文献类型：
--
作者：
Okude H;Ori D;Kawai T
模式识别受体（PRR）对病原体来源的核酸的识别对于通过诱导 I 型干扰素（IFN）和促炎细胞因子的产生来引发抗病毒免疫反应至关重要。这种反应是产生先天性和病原体特异性适应性免疫反应的先决条件。然而，宿主细胞也使用核酸作为遗传信息的载体，PRR对自身核酸的异常识别与自身免疫或自身炎症疾病的发生有关。在这篇综述中，我们描述了 PRR 的核酸传感机制，包括 Toll 样受体、RIG-I 样受体和 DNA 传感器分子，及其信号通路，以及这些 PRR 不受控制或不必要的激活引起的疾病。
Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is essential for eliciting antiviral immune responses by inducing the production of type I interferons (IFNs) and proinflammatory cytokines. Such responses are a prerequisite for mounting innate and pathogen-specific adaptive immune responses. However, host cells also use nucleic acids as carriers of genetic information, and the aberrant recognition of self-nucleic acids by PRRs is associated with the onset of autoimmune or autoinflammatory diseases. In this review, we describe the mechanisms of nucleic acid sensing by PRRs, including Toll-like receptors, RIG-I-like receptors, and DNA sensor molecules, and their signaling pathways as well as the disorders caused by uncontrolled or unnecessary activation of these PRRs.
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染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
影响因子：
29.7
作者：
Brubaker SW;Bonham KS;Zanoni I;Kagan JC
通讯作者：
Kagan JC
影响因子：
64.8
作者：
Alexopoulou, L;Holt, AC;Flavell, RA
通讯作者：
Flavell, RA
影响因子：
3.1
作者：
Cario, E;Podolsky, DK
通讯作者：
Podolsky, DK
影响因子：
64.5
作者：
Barnett, Katherine C.;Coronas-Serna, Julia M.;Kagan, Jonathan C.
通讯作者：
Kagan, Jonathan C.