Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease.
Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer's disease.
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DOI：
10.1016/j.neurobiolaging.2021.02.012
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发表时间：
2021-07
影响因子：
4.2
通讯作者：
Coughlan C
中科院分区：
文献类型：
--
作者：
Bettcher BM;Olson KE;Carlson NE;McConnell BV;Boyd T;Adame V;Solano DA;Anton P;Markham N;Thaker AA;Jensen AM;Dallmann EN;Potter H;Coughlan C
在生理条件下，星形胶质细胞在记忆巩固中起形成作用；当星形胶质细胞失调时，会释放胶质原纤维酸性蛋白（GFAP），在动物研究中，GFAP与负面记忆结果有关。我们研究了114名老年人（无症状，n=69； MCI/AD痴呆，n=45）血液GFAP、记忆和白质（WM）完整性之间的关系，考虑了AD病理（即Aβ42）和神经退行性变（即总tau蛋白；神经丝轻链）的血液标志物。较高水平的GFAP与较低的记忆评分相关（p<0.0001），因此GFAP平均值每增加一个SD，记忆综合评分平均下降0.49（标准误差=0.071）。在控制诊断状态和ad相关血液生物标志物后，这些结果仍然显着。在易受AD病理影响的区域，较高的GFAP也与较低的WM完整性相关；然而，WM完整性并不能解释GFAP和记忆之间的关联。研究结果表明，与淀粉样蛋白或神经变性标志物无关，血液中星形胶质细胞增生标志物的较高水平可能反映了记忆功能和白质健康状况的恶化。
Astrocytes play a formative role in memory consolidation during physiological conditions; when dysregulated, astrocytes release glial fibrillary acidic protein (GFAP), which has been linked with negative memory outcomes in animal studies. We examined the association between blood GFAP, memory, and white matter (WM) integrity, accounting for blood markers of AD pathology (i.e., Aβ42) and neurodegeneration (i.e., total tau; neurofilament light chain) in 114 older adults (asymptomatic, n=69; MCI/AD dementia, n=45). Higher levels of GFAP were associated with lower memory scores (p<0.0001), such that for one SD increase in mean GFAP values, the memory composite score decreased on average by 0.49 (Standard error=0.071). These results remained significant after controlling for diagnostic status and AD-related blood biomarkers. Higher GFAP was also related to lower WM integrity in regions vulnerable to AD pathology; however, WM integrity did not account for the association between GFAP and memory. Study findings suggest that higher blood levels of a marker of astrogliosis may reflect impoverished memory functions and white matter health, independent of markers of amyloid or neurodegeneration.
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影响因子：
4.3
作者：
Harada K;Kamiya T;Tsuboi T
通讯作者：
Tsuboi T
影响因子：
16.6
作者：
Koizumi K;Hattori Y;Ahn SJ;Buendia I;Ciacciarelli A;Uekawa K;Wang G;Hiller A;Zhao L;Voss HU;Paul SM;Schaffer C;Park L;Iadecola C
通讯作者：
Iadecola C
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
影响因子：
5.7
作者：
Barrick, Thomas R.;Charlton, Rebecca A.;Markus, Hugh S.
通讯作者：
Markus, Hugh S.
影响因子：
4
作者：
Chatterjee, Pratishtha;Elmi, Mitra;Martins, Ralph N.
通讯作者：
Martins, Ralph N.