Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units.
Effectiveness of Borage plus syrup on COVID-19 patients in intensive care units.
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DOI：
10.3389/fnut.2022.975937
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发表时间：
2022
影响因子：
5
通讯作者：
Adcock, Ian M.
中科院分区：
文献类型：
--
作者：
Hashemian, Seyed MohammadReza;Mortaz, Esmaeil;Shafigh, Navid;Ziaie, Shadi;Jamaati, Hamidreza;Hasheminik, Morteza;Jamalinik, Mehdi;Erfani, Raziyeh;Khoundabi, Batoul;Dezfuli, Neda K.;Varahram, Mohammad;Ahmadi, Shahrzad;Fahimi, Mahdi;Adcock, Ian M.
新冠肺炎(冠状病毒病-2019年)在全球范围内仍然造成很高的死亡率，没有明确的治疗方法。传统植物罗非菜(Borago office inalisL.)是伽马亚麻酸(GLA)的很好来源。我们假设萝卜汁加糖浆(BPS)对重症监护病房(ICU)中的重症新冠肺炎患者是有益的。进行了一项试验性的单中心随机试验，不含安慰剂。2020年6月至2020年12月在伊朗德黑兰Masih Daneshvari医院住进ICU的60名PCr阳性的重症新冠肺炎患者给予了知情同意。受试者被随机分成两组，一组为5ml加罗非鱼糖浆(BPS)，共5天；另一组为标准护理组(干扰素-β和法维拉韦)，每组30例。分别于入院时和出院时测定PaO2/FiO2、血清铁蛋白、C反应蛋白、胆红素、IL-6、肿瘤坏死因子-α、丙氨酸氨基转移酶、谷草转氨酶、红细胞压积和血清IL-8。经BPS治疗后，所有测量参数均显著降低。对照组除AST、PCT外，其余各项指标均有明显改善。此外，补肾活血方组对血清肿瘤坏死因子水平的抑制作用大于对照组(P≤.0 5)。且BPS组ICU住院时间明显低于对照组(P≤0.0 5)。我们的研究表明，在ICU的新冠肺炎患者的标准治疗方案中增加BPS可以改善预后并缩短ICU治疗时间。天然产品可以被认为是减少新冠肺炎有害后果的新方法。
COVID-19 (coronavirus disease-2019) still causes a high rate of death globally with no definite curative treatment described. The traditional plant Borage (Borago officinalis L.) is a good source of gamma-linolenic (GLA). We hypothesized that Borage plus syrup (BPS) would be beneficial in severe COVID-19 patients within an intensive care unit (ICU) setting. A pilot single center, randomized trial with no placebo was undertaken. A total of 60 PCR-positive severe COVID-19 participants admitted to ICU from June 2020–December 2020 at Masih Daneshvari Hospital Tehran-Iran gave informed consent. The participants were randomly assigned to either Borage Plus Syrup (BPS, 5 ml for 5 days) (n = 30) or standard care (IFN-β and favipiravir) as a control group (n = 30). Pao2/Fio2, serum ferritin, CRP, bilirubin, IL-6, TNF-α, ALT, AST, PCT and serum IL-8 was measured upon admission and on release. All the measured parameters decreased significantly with BPS treatment. In the control group, most parameters significantly improved apart from AST and PCT. In addition, the suppression of serum TNF levels in the BPS group was greater than that seen in the control group (P ≤ 0.05). Moreover, the length of ICU stay was significantly lower in the BPS group compared with the control group (P ≤ 0.05). Our study shows that addition of BPS to the standard treatment regime of COVID-19 patients in ICU improved outcomes and reduced the length of ICU treatment. Natural products could be considered as new approaches for reducting the harmful consequences of COVID-19.
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影响因子：
1.5
作者：
Al-Okbi, Sahar Y.;El-qousy, Salah M.;Moawa, Hosam F.
通讯作者：
Moawa, Hosam F.
影响因子：
4.6
作者：
Goc A;Niedzwiecki A;Rath M
通讯作者：
Rath M
影响因子：
1.9
作者：
RAEDERSTORFF, D;MOSER, U
通讯作者：
MOSER, U
DOI：
10.1016/j.nut.2020.111052
发表时间：
2021-03
期刊：
Nutrition (Burbank, Los Angeles County, Calif.)
影响因子：
--
作者：
Das UN
通讯作者：
Das UN
影响因子：
3.4
作者：
Abolhassani, Mohsen
通讯作者：
Abolhassani, Mohsen