Hyper-responsive phenotype in localized aggressive periodontitis.
Hyper-responsive phenotype in localized aggressive periodontitis.
复制标题
DOI：
10.1177/0022034509353397
复制
发表时间：
2010-02
影响因子：
7.6
通讯作者：
Wallet SM
中科院分区：
文献类型：
--
作者：
Shaddox L;Wiedey J;Bimstein E;Magnuson I;Clare-Salzler M;Aukhil I;Wallet SM
“高反应性”的特征是在刺激先天免疫受体时炎症反应增加。我们的目标是确定在被诊断为侵袭性牙周炎(LAgP)的队列中是否存在高反应特征。采集30例LAgP患者、10例健康无血缘关系患者和10例健康同胞外周血，用大肠杆菌和牙龈假单胞菌的脂多糖(LPS)刺激。用单因素方差分析方法评价和分析细胞/趋化因子反应谱。与健康的无血缘关系的对照组相比，在大肠杆菌和牙龈假单胞菌的LAgP培养中，检测到促炎细胞/趋化因子的水平升高。牙周健康的兄弟姐妹表现为减弱的高炎症细胞/趋化因子特征。回归分析表明，高反应的特征是伴随着促炎细胞/趋化因子的表达，而缺乏抗炎介质的表达。我们的发现在LAgP队列中显示出高反应特征，同时在健康的兄弟姐妹中表现出减弱的高反应，这可以在多次TLR连接时诱导。
The ‘hyper-responsive’ trait is an increased inflammatory response upon stimulation of innate immune receptors. Our objective was to determine if a hyper-reactive trait is present in a cohort diagnosed with aggressive periodontitis (LAgP). Peripheral blood was collected from 30 LAgP, 10 healthy unrelated, and 10 healthy sibling participants and stimulated with lipopolysaccharide (LPS) from E. coli and P. gingivalis. Cyto/chemokine response profiles were evaluated and analyzed by ANOVA. Elevated levels of pro-inflammatory cyto/chemokines were detected in E. coli and P. gingivalis LPS-stimulated LAgP cultures when compared with those of healthy unrelated control individuals. Periodontally healthy siblings presented with attenuated hyper-inflammatory cyto/chemokine profiles. Regression analysis demonstrated the hyper-reactive trait to be concomitant expression of pro-inflammatory cyto/chemokines and an absence of anti-inflammatory mediator expression. Our findings demonstrate hyper-responsive trait in a LAgP cohort, along with an attenuated hyper-responsiveness in healthy siblings, which can be induced in response to multiple TLR ligations.
登录
查看更多内容
影响因子：
4.4
作者：
Mohammad, Mohammad K.;Morran, Michael;McInerney, Marcia F.
通讯作者：
McInerney, Marcia F.
影响因子：
6.5
作者：
Naguib, G;Al-Mashat, H;Graves, DT
通讯作者：
Graves, DT
影响因子：
20.3
作者：
Han, JH;Choi, SJ;Roodman, GD
通讯作者：
Roodman, GD
影响因子：
6.7
作者：
Salvi, GE;Collins, JG;Offenbacher, S
通讯作者：
Offenbacher, S
影响因子：
2
作者：
Kinane, DF;Lappin, DF
通讯作者：
Lappin, DF