The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms.
The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms.
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DOI：
10.1371/journal.pone.0065547
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hayley S
中科院分区：
文献类型：
--
作者：
Caldwell W;McInnis OA;McQuaid RJ;Liu G;Stead JD;Anisman H;Hayley S
脑源性神经营养因子（BDNF）信号传导的紊乱与抑郁症的演变有关，抑郁症的发生可能部分是由于突触可塑性减弱。可以预见的是，考虑到抑郁症中的压力源，脑源性神经营养因子会受到最近的压力源以及早年经历的忽视等压力源的影响。早期生活中的虐待改变BDNF信号的影响可能在具有特定BDNF多态性的个体中特别明显。我们研究了Val 66 Met基因型的多态性是否可能在调节早期生活事件如何与后来的应对方式，认知灵活性和抑郁特征有关方面产生影响。在男性和女性的本科生（N = 124），童年忽视是高度相关的随后的抑郁症状。 这一结果被调节的BDNF多态性的意义上，抑郁症状出现在甲硫氨酸携带者谁报告低水平的忽视比那些与瓦尔/瓦尔等位基因。然而，在高度忽视的情况下，抑郁症状只在瓦尔/瓦尔个体中增加。实际上，Met多态性与抑郁特征相关，但在预测后期抑郁特征时与早期生活忽视没有相互作用。进一步观察到，在瓦尔/瓦尔个体中，忽视和抑郁之间的关系是由情绪集中的风格和减少感知控制介导的，而这种介导在Met携带者中不明显。与关于这种多态性的更典型的观点相反，数据与以下观点一致：在突触可塑性的存在下，可能与瓦尔/瓦尔基因型相关，忽视允许出现特定的评价和应对方式，这与抑郁症有关。在Met携带者预期神经可塑性程度降低的情况下，早期生活中的不良经历与应对方式无关，因此不太可能转化为抑郁状态。
Disturbances of brain derived neurotrophic factor (BDNF) signalling have been implicated in the evolution of depression, which likely arises, in part, as a result of diminished synaptic plasticity. Predictably, given stressor involvement in depression, BDNF is affected by recent stressors as well as stressors such as neglect experienced in early life. The effects of early life maltreatment in altering BDNF signalling may be particularly apparent among those individuals with specific BDNF polymorphisms. We examined whether polymorphisms of the Val66Met genotype might be influential in moderating how early-life events play out with respect to later coping styles, cognitive flexibility and depressive features. Among male and female undergraduate students (N = 124), childhood neglect was highly related to subsequent depressive symptoms. This outcome was moderated by the BDNF polymorphism in the sense that depressive symptoms appeared higher in Met carriers who reported low levels of neglect than in those with the Val/Val allele. However, under conditions of high neglect depressive symptoms only increased in the Val/Val individuals. In effect, the Met polymorphism was associated with depressive features, but did not interact with early life neglect in predicting later depressive features. It was further observed that among the Val/Val individuals, the relationship between neglect and depression was mediated by emotion-focused styles and diminished perceived control, whereas this mediation was not apparent in Met carriers. In contrast to the more typical view regarding this polymorphism, the data are consistent with the perspective that in the presence of synaptic plasticity presumably associated with the Val/Val genotype, neglect allows for the emergence of specific appraisal and coping styles, which are tied to depression. In the case of the reduced degree of neuroplasticity expected in the Met carriers, early life adverse experiences are not tied to coping styles, and hence less likely to be translated into depressive states.
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影响因子：
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