Theranostics Using Indocyanine Green Lactosomes.
Theranostics Using Indocyanine Green Lactosomes.
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DOI：
10.3390/cancers14153840
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发表时间：
2022-08-08
期刊：
影响因子：
5.2
通讯作者：
Hayashi, Mikio
中科院分区：
文献类型：
--
作者：
Kaibori, Masaki;Matsui, Kosuke;Hayashi, Mikio
乳体™是生物相容性纳米颗粒，可用于癌症组织成像和药物输送。乳小体是两亲性胶束，其粒径可控制在20 ~ 100nm范围内。乳小体也可以装载成像探针和抗癌剂。吲哚菁绿色负载乳小体在癌症组织中积累，并作为光敏剂发挥作用，同时使诊断和光动力治疗成为可能。这种方法可以促进不可切除组织中癌症的治疗，从而提高患者的生活质量。本文综述了乳小体的分子设计、在癌症组织中的积累和治疗应用。我们还讨论了一些悬而未决的问题和癌症治疗的未来方向。乳体™是生物相容性纳米颗粒，可用于癌症组织成像和药物输送。乳小体是由亲水性聚arcos和疏水性聚l -乳酸链组成的可生物降解的两亲嵌段共聚物自组装形成的聚合物胶束。粒径可控制在20 ~ 100nm范围内。乳小体也可以装载疏水成像探针和光敏剂，如吲哚菁绿。含有吲哚菁绿的乳小体在血液中的长期循环是稳定的，允许在癌症组织中积累。这种乳小体具有光敏剂的功能，可以同时实现荧光诊断和光动力治疗。本文综述了乳小体的分子设计、在癌组织中的积累和治疗应用。乳小体的使用可以促进不可切除组织中癌症的治疗，如胶质母细胞瘤和头颈部癌症，这可以改善复发性和不可切除癌症患者的生活质量。最后，我们描述了癌症治疗在临床应用方面的一些突出问题和未来方向。
Lactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are amphiphilic micelles in which the particle size can be controlled in the range of 20 to 100 nm. Lactosomes can also be loaded with imaging probes and anticancer agents. Indocyanine green-loaded lactosomes accumulate in cancer tissues and function as a photosensitizer, which simultaneously enables diagnosis and photodynamic therapy. This approach can facilitate the treatment of cancers in unresectable tissues, which can lead to improved quality of life for patients. This review provides an overview of lactosomes with respect to molecular design, accumulation in cancer tissues, and theranostics applications. We also address some outstanding questions and future directions in cancer theranostics. Lactosomes™ are biocompatible nanoparticles that can be used for cancer tissue imaging and drug delivery. Lactosomes are polymeric micelles formed by the self-assembly of biodegradable amphiphilic block copolymers composed of hydrophilic polysarcosine and hydrophobic poly-L-lactic acid chains. The particle size can be controlled in the range of 20 to 100 nm. Lactosomes can also be loaded with hydrophobic imaging probes and photosensitizers, such as indocyanine green. Indocyanine green-loaded lactosomes are stable for long-term circulation in the blood, allowing for accumulation in cancer tissues. Such lactosomes function as a photosensitizer, which simultaneously enables fluorescence diagnosis and photodynamic therapy. This review provides an overview of lactosomes with respect to molecular design, accumulation in cancer tissue, and theranostics applications. The use of lactosomes can facilitate the treatment of cancers in unresectable tissues, such as glioblastoma and head and neck cancers, which can lead to improved quality of life for patients with recurrent and unresectable cancers. We conclude by describing some outstanding questions and future directions for cancer theranostics with respect to clinical applications.
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影响因子：
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