Clues from the Pandora's Box: Frequency of Acute Abdominal Symptoms in COVID-19 and Its Association with Inflammatory Markers-a Cross-Sectional Study.
Clues from the Pandora's Box: Frequency of Acute Abdominal Symptoms in COVID-19 and Its Association with Inflammatory Markers-a Cross-Sectional Study.
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DOI：
10.1007/s12262-022-03550-w
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发表时间：
2022-08-22
影响因子：
0.4
通讯作者：
Gupta, Anupam
中科院分区：
文献类型：
--
作者：
Madan, K.;Rudresh, H. K.;Rao, Akshay;Sandeep, S.;Monica, N.;Gupta, Anupam
2019 年冠状病毒病 (COVID-19) 主要被认为是一种呼吸系统疾病。迄今为止，急性 COVID-19 中腹部症状的报道频率各不相同。本研究的目的是估计因 COVID-19 感染而住院的患者出现腹部症状的频率，并确定其与疾病严重程度的关系。这是一项在 COVID-19 三级护理医院进行的单中心横断面观察研究（CTRI/2021/10/037195，注册于 2021 年 8 月 10 日）。研究期间连续因急性 COVID-19 疾病住院的患者被纳入该研究。获取了他们的人口统计信息、腹部症状、合并症和 COVID-19 疾病类别。所有患者在住院当天均进行了血清炎症标志物检测。在 685 名参与者中，214 名患者患有轻度至中度疾病，其余 471 名患者患有严重的 COVID-19 疾病。 132/685（18.3%）名患者有腹部主诉，其中腹胀（8.03%）是最常见的症状，其次是呕吐（6.72%）和腹痛（3.94%）。入院时，重度疾病患者比轻至中度疾病患者更常见腹部不适（101/471 vs. 31/214；p=0.029）。腹部症状与较高的中性粒细胞与淋巴细胞比率相关（p=0.029）。有腹部症状的 COVID-19 患者的死亡率较高（9.09% vs. 3.25%；p = 0.007）。这项研究展示了住院期间急性 COVID-19 可能出现的一系列腹部症状，并强调了它们在急性 COVID-19 感染中的预后潜力。
Coronavirus disease 2019 (COVID-19) is primarily considered to be a respiratory ailment. Hitherto, abdominal symptoms have been reported with variable frequency in acute COVID-19. The purpose of this study was to estimate the frequency of abdominal symptoms at presentation among patients hospitalised with COVID-19 infection, and to determine their association with disease severity. This was a single-centre cross-sectional observational study conducted at a COVID-19 tertiary care hospital (CTRI/2021/10/037195, registered on 08/10/2021). Consecutive patients hospitalised with acute COVID-19 illness during the study period were included in the study. Their demographic information, abdominal symptoms, comorbidities and category of COVID-19 illness were elicited. All patients had serum inflammatory markers tested on the day of hospitalisation. Among the 685 participants, 214 patients had mild-to-moderate category illness whereas the rest 471 had severe COVID-19 illness. Abdominal complaints were present among 132/685 (18.3%) patients with distension of abdomen (8.03%) being the most common symptom, followed by vomiting (6.72%) and abdominal pain (3.94%). At admission to the hospital, abdominal complaints were commoner among patients with severe disease than in those with mild-to-moderate disease (101/471 vs. 31/214; p=0.029). Abdominal symptoms were associated with a higher neutrophil to lymphocyte ratio (p=0.029). The mortality among COVID-19 patients with abdominal symptoms was higher (9.09 vs. 3.25%; p = 0.007). This study demonstrates the spectrum of abdominal symptoms that can be a part of acute COVID-19 at hospitalisation and also highlights their prognostic potential in acute COVID-19 infection.
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DOI：
10.1016/j.tige.2021.01.006
发表时间：
2021
影响因子：
2.4
作者：
Vespa E;Pugliese N;Colapietro F;Aghemo A
通讯作者：
Aghemo A
影响因子：
3.9
作者：
Chen R;Yu YL;Li W;Liu Y;Lu JX;Chen F;Zhou Q;Xia ZY;Gao L;Meng QT;Ma D
通讯作者：
Ma D
影响因子：
82.9
作者：
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通讯作者：
HCA Lung Biological Network
影响因子：
29.4
作者：
Redd, Walker D.;Zhou, Joyce C.;Chan, Walter W.
通讯作者：
Chan, Walter W.
影响因子：
1.9
作者：
Pan, Tao;Li, Ming-an;Li, Zheng-ran
通讯作者：
Li, Zheng-ran