Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes.
Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes.
复制标题
糖尿病前期和 2 型糖尿病受试者的血浆 C1q/TNF 相关蛋白 3 (CTRP-3) 和高迁移率族 Box-1 (HMGB-1) 浓度
DOI：
10.1155/2016/9438760
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发表时间：
2016
影响因子：
4.3
通讯作者：
Deng H
中科院分区：
文献类型：
--
作者：
Wei H;Qu H;Wang H;Deng H
目标。目的探讨C1q/肿瘤坏死因子相关蛋白-3(CTRP-3)和高迁移率族蛋白-1(HMGB-1)在糖尿病前期(Pre-DM)和新诊断的2型糖尿病(NT2 DM)中的相关性。纳入了224名符合条件的参与者。测定75g口服葡萄糖耐量试验(OGTT)及代谢紊乱和细胞因子的临床指标。所有受试者分为正常糖耐量组(NGT，n=62)、糖尿病前期组(n=111)和2型糖尿病组(n=56)。糖尿病前期和2型糖尿病患者血浆CTRP-3水平明显低于NGT组，而HMGB-1水平明显高于NGT组(P<0.05)。多元线性回归分析显示，血浆CTRP-3和HMGB-1浓度与胰岛素抵抗(HOMA-IR)和白细胞介素6(IL-6)的稳态模型评估独立相关(P0.05)。进一步的多因素Logistic回归分析显示，血浆CTRP-3和HMGB-1水平与DM前和nT2 DM显著相关(P0.001)。循环CTRP-3和HMGB-1浓度可能是预测糖尿病前期和2型糖尿病的有前景的生物标志物。
Aims. To detect the association of C1q/TNF-related protein-3 (CTRP-3) and high-mobility group box-1 (HMGB-1) in subjects with prediabetes (pre-DM) and newly diagnosed type 2 diabetes (nT2DM).Methods. 224 eligible participants were included. The 75 g oral glucose tolerance test (OGTT) and several clinical parameters of metabolic disorders and cytokines were measured. All participants were divided into three groups: normal glucose tolerance (NGT,n=62), pre-DM (n=111), and nT2DM group (n=56).Results. Plasma CTRP-3 concentrations were significantly lower in subjects with pre-DM and nT2DM than that of the NGT group, while plasma HMGB-1 levels were higher in pre-DM and nT2DM group compared with the NGT group (P0.05). A multiple linear regression analysis showed both plasma CTRP-3 and HMGB-1 concentrations were independently associated with homeostasis model assessment for insulin resistance (HOMA-IR) and interleukin-6 (IL-6) (P0.05for all). Further multiple logistical regression analyses revealed that both plasma CTRP-3 and HMGB-1 levels were significantly associated with pre-DM and nT2DM after adjusting for several confounders (P0.001for all).Conclusions. Circulating CTRP-3 and HMGB-1 concentrations might be promising biomarkers to predict prediabetes and type 2 diabetes.
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影响因子：
5.1
作者：
Guariguata, L.;Whiting, D. R.;Shaw, J. E.
通讯作者：
Shaw, J. E.
影响因子：
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作者：
Schierbeck, Hanna;Wahamaa, Heidi;Harris, Helena Erlandsson
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影响因子：
4.4
作者：
Qu, Hua;Deng, Min;Deng, Huacong
通讯作者：
Deng, Huacong
影响因子：
16.2
作者：
Grossmann, Vera;Schmitt, Volker H.;Wild, Philipp S.
通讯作者：
Wild, Philipp S.
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影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM