Multiple wheat genomes reveal global variation in modern breeding.
Multiple wheat genomes reveal global variation in modern breeding.
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DOI：
10.1038/s41586-020-2961-x
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发表时间：
2020-12
期刊：
影响因子：
64.8
通讯作者：
Pozniak CJ
中科院分区：
文献类型：
--
作者：
Walkowiak S;Gao L;Monat C;Haberer G;Kassa MT;Brinton J;Ramirez-Gonzalez RH;Kolodziej MC;Delorean E;Thambugala D;Klymiuk V;Byrns B;Gundlach H;Bandi V;Siri JN;Nilsen K;Aquino C;Himmelbach A;Copetti D;Ban T;Venturini L;Bevan M;Clavijo B;Koo DH;Ens J;Wiebe K;N'Diaye A;Fritz AK;Gutwin C;Fiebig A;Fosker C;Fu BX;Accinelli GG;Gardner KA;Fradgley N;Gutierrez-Gonzalez J;Halstead-Nussloch G;Hatakeyama M;Koh CS;Deek J;Costamagna AC;Fobert P;Heavens D;Kanamori H;Kawaura K;Kobayashi F;Krasileva K;Kuo T;McKenzie N;Murata K;Nabeka Y;Paape T;Padmarasu S;Percival-Alwyn L;Kagale S;Scholz U;Sese J;Juliana P;Singh R;Shimizu-Inatsugi R;Swarbreck D;Cockram J;Budak H;Tameshige T;Tanaka T;Tsuji H;Wright J;Wu J;Steuernagel B;Small I;Cloutier S;Keeble-Gagnère G;Muehlbauer G;Tibbets J;Nasuda S;Melonek J;Hucl PJ;Sharpe AG;Clark M;Legg E;Bharti A;Langridge P;Hall A;Uauy C;Mascher M;Krattinger SG;Handa H;Shimizu KK;Distelfeld A;Chalmers K;Keller B;Mayer KFX;Poland J;Stein N;McCartney CA;Spannagl M;Wicker T;Pozniak CJ
基因组学的进步加速了几种重要农业作物的改良，但在小麦（Triticum spp.）变得更具挑战性这在很大程度上是由于小麦基因组的大小和复杂性，以及缺乏多个小麦品系的基因组组装数据。在这里，我们产生了十个染色体假分子和五个支架组装的六倍体小麦，以探索全球育种计划的小麦品系之间的基因组多样性。比较分析显示，广泛的结构重排，从野生亲缘关系和基因内容的差异，导致复杂的育种历史，旨在提高适应不同的环境，粮食产量和质量，并抗压力。我们提供的例子概述了这些基因组的效用，包括一个详细的多基因组衍生的核苷酸结合亮氨酸丰富的重复蛋白的剧目参与抗病性和Sm1，与抗虫性相关的基因的表征。这些基因组组装将为功能基因的发现和育种提供基础，以提供下一代现代小麦品种。小麦多个基因组组装的比较揭示了小麦复杂育种历史的广泛多样性，并为进一步改进这一重要粮食作物提供了基础。
Advances in genomics have expedited the improvement of several agriculturally important crops but similar efforts in wheat (Triticum spp.) have been more challenging. This is largely owing to the size and complexity of the wheat genome, and the lack of genome-assembly data for multiple wheat lines. Here we generated ten chromosome pseudomolecule and five scaffold assemblies of hexaploid wheat to explore the genomic diversity among wheat lines from global breeding programs. Comparative analysis revealed extensive structural rearrangements, introgressions from wild relatives and differences in gene content resulting from complex breeding histories aimed at improving adaptation to diverse environments, grain yield and quality, and resistance to stresses. We provide examples outlining the utility of these genomes, including a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disease resistance and the characterization of Sm1, a gene associated with insect resistance. These genome assemblies will provide a basis for functional gene discovery and breeding to deliver the next generation of modern wheat cultivars. Comparison of multiple genome assemblies from wheat reveals extensive diversity that results from the complex breeding history of wheat and provides a basis for further potential improvements to this important food crop.
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影响因子：
5.9
作者：
Brinton J;Ramirez-Gonzalez RH;Simmonds J;Wingen L;Orford S;Griffiths S;10 Wheat Genome Project;Haberer G;Spannagl M;Walkowiak S;Pozniak C;Uauy C
通讯作者：
Uauy C
影响因子：
7.2
作者：
Cheng, Shifeng;Gutmann, Bernard;Small, Ian
通讯作者：
Small, Ian
影响因子：
3.1
作者：
DVORAK, J;MCGUIRE, PE;CASSIDY, B
通讯作者：
CASSIDY, B
影响因子：
56.9
作者：
Avni, Raz;Nave, Moran;Distelfeld, Assaf
通讯作者：
Distelfeld, Assaf
影响因子：
12.3
作者：
Harewood L;Kishore K;Eldridge MD;Wingett S;Pearson D;Schoenfelder S;Collins VP;Fraser P
通讯作者：
Fraser P