Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex.

Pulmonary disease in children with acquired immune deficiency syndrome and AIDS-related complex.
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患有获得性免疫缺陷综合症和艾滋病相关综合症的儿童的肺部疾病。

DOI:
10.1016/s0022-3476(86)80822-8
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发表时间:
1986
期刊:
The Journal of pediatrics
影响因子:
--
通讯作者:
Goldman,H
Goldman,H
中科院分区:
--
文献类型:
--
作者:
Rubinstein,A;Morecki,R;Silverman,B;Charytan,M;Krieger,BZ;Andiman,W;Ziprkowski,MN;Goldman,H

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根据15例获得性免疫缺陷综合征(AIDS)或AIDS相关综合征患儿的肺活检,确定了两种主要肺部疾病。在8名儿童中观察到卡氏肺孢子虫肺炎,在6名儿童中观察到肺淋巴样增生。1例患儿发生非特异性间质性肺炎。卡氏肺孢子虫肺炎患儿有更严重的低氧血症,肺泡-动脉氧分压差更高,血清乳酸脱氢酶同形升高更高。临床上,肺淋巴组织增生的儿童年龄较大,并有手指杵状突起,腮腺肿大,血清IgG水平升高。血清学检测和肺组织分析结果提示持续性EB病毒感染仅见于肺淋巴组织增生患者。识别每个实体的临床和实验室特征可能有助于鉴别诊断,而不需要手术活检。
Two major pulmonary diseases were defined on the basis of lung biopsies in 15 children with acquired immune deficiency syndrome (AIDS) or AIDS-related complex. Pneumocystis carinii pneumonia was observed in eight children, and pulmonary lymphoid hyperplasia in six. One child had nonspecific interstitial pneumonitis. Children with P. carinii pneumonia had more severe hypoxemia, with higher alveolar-arterial oxygen gradients, and higher isomorphic elevations of serum lactate dehydrogenase. Clinically, children with pulmonary lymphoid hyperplasia were older, and had digital clubbing, parotid gland enlargement, and elevated serum IgG levels. Results of serologic assays and lung tissue analysis were suggestive of persistent Epstein-Barr virus infection exclusively in patients with pulmonary lymphoid hyperplasia. Recognition of the clinical and laboratory findings characteristic of each entity may assist in the differential diagnosis without the need of surgical biopsy.
恶性淋巴瘤并发淋巴细胞间质性肺炎:一种由多克隆淋巴细胞增殖性疾病引起的单克隆 B 细胞肿瘤。
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