Delayed cognitive impairments in a rat model of Gulf War Illness are stimulus-dependent
Delayed cognitive impairments in a rat model of Gulf War Illness are stimulus-dependent
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海湾战争病大鼠模型中的迟发性认知障碍是刺激依赖性的
DOI：
10.1016/j.bbi.2023.07.003
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Grillo, C.A.
中科院分区：
文献类型：
--
作者：
Burzynski, H.E.;Ayala, K.E.;Frick, M.A.;Dufala, H.A.;Woodruff, J.L.;Macht, V.A.;Eberl, B.R.;Hollis, F.;McQuail, J.A.;Grillo, C.A.
海湾战争病（GWI）集中描述了影响1990-1991年海湾战争中服役的士兵的大量中心和外围干扰。虽然负责GWI的机制仍然难以捉摸，可逆的乙酰胆碱酯酶抑制剂，溴化吡啶斯的明（PB）的预防性使用，和战争相关的压力已被确定为GWI病理的主要因素。部署后压力是退伍军人面临的常见挑战，并且对这些心理压力源的异常胆碱能和/或免疫反应可能在GWI病理学中起重要作用，特别是许多GWI患者经历的认知障碍。因此，本研究调查了三个月后固定应激挑战是否会在PB处理的大鼠中产生异常反应。结果表明，海马胆碱能反应的制动应激挑战受损三个月后PB管理。我们还评估了在这个延迟的时间点，免疫或应激挑战是否揭示了PB处理的动物在海马依赖性学习和记忆任务中的缺陷。新的物体识别（NOR）测试与急性盐水或脂多糖（LPS，30 µg/kg，i. p.）配对，以及在PB给药和/或重复束缚应激后约三个月进行Morris水迷宫（MWM）测试。在NOR任务中，有PB治疗史的大鼠在用LPS而不是盐水挑战时表现出24小时的海马依赖性记忆缺陷。同样，在同一队列中，PB处理的大鼠在MWM任务中表现出24小时记忆缺陷。最终，这些研究强调了PB治疗对海马功能的长期影响，并提供了对GWI退伍军人中观察到的进行性认知缺陷的深入了解。
Gulf War Illness (GWI) collectively describes the multitude of central and peripheral disturbances affecting soldiers who served in the 1990–1991 Gulf War. While the mechanisms responsible for GWI remain elusive, the prophylactic use of the reversible acetylcholinesterase inhibitor, pyridostigmine bromide (PB), and war-related stress have been identified as chief factors in GWI pathology. Post-deployment stress is a common challenge faced by veterans, and aberrant cholinergic and/or immune responses to these psychological stressors may play an important role in GWI pathology, especially the cognitive impairments experienced by many GWI patients. Therefore, the current study investigated if an immobilization stress challenge would produce abnormal responses in PB-treated rats three months later. Results indicate that hippocampal cholinergic responses to an immobilization stress challenge are impaired three months after PB administration. We also assessed if an immune or stress challenge reveals deficits in PB-treated animals during hippocampal-dependent learning and memory tasks at this delayed timepoint. Novel object recognition (NOR) testing paired with either acute saline or lipopolysaccharide (LPS, 30 µg/kg, i.p.), as well as Morris water maze (MWM) testing was conducted approximately three months after PB administration and/or repeated restraint stress. Rats with a history of PB treatment exhibited 24-hour hippocampal-dependent memory deficits when challenged with LPS, but not saline, in the NOR task. Similarly, in the same cohort, PB-treated rats showed 24-hour memory deficits in the MWM task. Ultimately, these studies highlight the long-term effects of PB treatment on hippocampal function and provide insight into the progressive cognitive deficits observed in veterans with GWI.
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海湾战争退伍军人的神经心理功能：与自我报告的有毒物质暴露的关系。
影响因子：
3.5
作者：
R. F. White;S. Proctor;T. Heeren;J. Wolfe;M. Krengel;J. Vasterling;K. Lindem;K. Heaton;P. Sutker;D. Ozonoff
通讯作者：
D. Ozonoff
影响因子：
3.3
作者：
Fadel, J;Pasumarthi, R;Reznikov, LR
通讯作者：
Reznikov, LR
DOI：
--
发表时间：
1972
期刊：
影响因子：
--
作者：
Jack H. Ornstein
通讯作者：
Jack H. Ornstein
DOI：
10.1097/jom.0b013e3181a2feeb
发表时间：
2009-04-01
影响因子：
3.2
作者：
Kang, Hang K.;Li, Bo;Engel, Charles C.
通讯作者：
Engel, Charles C.
海湾战争特工暴露小鼠模型中神经行为和神经病理学认知损伤的慢性纵向特征
影响因子：
3.5
作者：
Z. Zakirova;Gogce Crynen;Samira Hassan;L. Abdullah;Lauren Horne;V. Mathura;F. Crawford;G. Ait
通讯作者：
G. Ait