Comparison of brain white matter hyperintensities in methamphetamine and methadone dependent patients and healthy controls.
Comparison of brain white matter hyperintensities in methamphetamine and methadone dependent patients and healthy controls.
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DOI：
10.5812/iranjradiol.14275
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Khoddad T
中科院分区：
文献类型：
--
作者：
Alaee A;Zarghami M;Farnia S;Khademloo M;Khoddad T
先前的研究已证明甲基苯丙胺和阿片类药物使用者会出现白质高信号（WMH）。阿片类药物和甲基苯丙胺 (MA) 是伊朗最常见的成瘾物质。药物对中枢神经系统的不良影响是专家和研究人员关注的问题，考虑到甲基苯丙胺的神经毒性大于阿片类药物，因此推测甲基苯丙胺依赖患者的 WMH 严重程度高于阿片类药物依赖者。据我们所知，这是第一项比较甲基苯丙胺和美沙酮 (M) 对大脑影响的研究。在一项历史队列研究中，我们比较了 50 名甲基苯丙胺依赖患者、50 名美沙酮依赖患者和 50 名年龄、性别和惯用手相匹配的健康志愿者的脑部 MRI 中的 WMH。在 18 名甲基苯丙胺使用者、12 名美沙酮使用者和 7 名对照者中检测到 WMH（P = 0.038）。 MA使用者脑部病变部位多位于额叶17例，M使用者额叶12例，对照组4例顶叶（P=0.001）。额叶是 MA 和 M 组 WMH 的主要部位（P = 0.001）。 MA使用者18例，M使用者12例，对照组2例，脑部病变多发生在深部WM（P=0.007）。 MA组深部WM高信号灶为I级（点状）12例，II级（开始汇合）5例，III级（大汇合）4例。 M组Ⅰ级6例，Ⅱ级3例，Ⅲ级1例。对照组中，Ⅰ级病例3例，Ⅱ级病例2例，无Ⅲ级病例。除室周WMH（P=0.13）外，三组间深部WMH（P=0.007）和皮层下WMH（P=0.01）差异均有统计学意义。使用其他药物的历史以及MA和M消耗的持续时间相似。与健康对照组相比，两个吸毒者群体的脑损伤患病率普遍较高。 MA组WMH的增加高于M组。与阿片类药物使用者相比，MA 使用者大脑中存在更多的血流缺陷和缺血性病变，这可能解释了这些患者精神疾病的流行。
Previous studies have proven the development of white matter hyperintensities (WMH) in methamphetamine and opioid users. Opiates and methamphetamines (MA) are the most common addictive agents in Iran. The adverse effects of drugs on the CNS is of concern to specialists and researchers, and given that the neurotoxicity associated with methamphetamine is greater than opioids, it is hypothesized that the severity of WMH in patients with methamphetamine dependence is more than opioid drug-dependent individuals. To our knowledge, this is the first research comparing the effect of methamphetamine and methadone (M) on the brain. In a historical cohort study, we compared WMH in the brain MRI of 50 methamphetamine-dependent patients, 50 methadone-dependent patients and 50 healthy volunteers who were matched for age, sex and dominant hand. WMH was detected in 18 methamphetamine users, in 12 methadone users and in seven controls (P = 0.038). The site of brain lesions in MA users was mostly in the frontal lobe in 17 cases, in M users in the frontal lobe in 12 cases and in the control group, it was in the parietal lobe in four cases (P=0.001). The frontal lobes were the predominant locations of WMH in MA and M groups (P = 0.001). The frequency of brain lesions was mostly in the deep WM in 18 cases in MA users, in 12 cases in M users and in two cases in the control group (P=0.007). Hyper-signal foci of deep WM in the MA group were grade I (punctuate) in 12 cases, grade II (beginning confluence) in five cases and grade III (large confluent) in four cases. In the M group, there were six cases in grade I, three cases in grade II and one case in grade III. In the control group, there were three grade I cases, two grade II cases, and no grade III cases. Except for periventricular WMH (P = 0.13), there were statistical significant differences in the deep WMH (P = 0.007) and subcortex WMH (P = 0.01) between the three groups. The history of using other drugs and the duration of MA and M consumption were similar. The prevalence of brain lesions was generally higher in both drug user groups compared with the healthy controls. Increased WMH in the MA group was higher than the M group. A greater number of blood flow defects and ischemic lesions in the brain of MA users compared to opiate users may explain the prevalence of psychiatric disorders in these patients.
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影响因子：
2.1
作者：
Yin, Jing-Jing;Ma, Shu-Hua;Cai, Ze-Long
通讯作者：
Cai, Ze-Long
影响因子：
4.2
作者：
Compton WM;Dawson DA;Goldstein RB;Grant BF
通讯作者：
Grant BF
影响因子：
4.5
作者：
Riddle, Evan L.;Fleckenstein, Annette E.;Hanson, Glen R.
通讯作者：
Hanson, Glen R.
DOI：
10.1017/sl461145706007395
发表时间：
2007-12-01
影响因子：
4.8
作者：
Chung, Ain;Lyoo, In Kyoon;Renshaw, Perry F.
通讯作者：
Renshaw, Perry F.
影响因子：
6
作者：
Chang, Linda;Alicata, Daniel;Volkow, Nora
通讯作者：
Volkow, Nora