Bacterial conversion of a host weapon into a nutritional signal.

Bacterial conversion of a host weapon into a nutritional signal.
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DOI:
10.1016/j.jbc.2022.102600
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发表时间:
2022-11
影响因子:
4.8
通讯作者:
Valvano, Miguel A.
Valvano, Miguel A.
中科院分区:
生物学2区
文献类型:
--
作者:
Valvano, Miguel A.

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被吞噬细胞吞噬的细菌必须抵抗氧化损伤,适应细胞缺氧,但参与这一过程的机制尚未完全阐明。Kim等人最近的工作。在《生物化学杂志》上,研究了细胞内病原体肠沙门氏菌如何激活对抗氧化损伤所需的基因表达。作者证明,这种细菌利用宿主氧化分子激活调节蛋白,从而增加效应器分子的产生,抵消宿主武器NADPH氧化酶,并诱导保护性反应。
Bacteria engulfed by phagocytic cells must resist oxidation damage and adapt to cellular hypoxia, but the mechanisms involved in this process are not completely elucidated. Recent work by Kim et al. in the Journal of Biological Chemistry investigated how the intracellular pathogen Salmonella enterica activates gene expression required to counteract oxidative damage. The authors show that this bacterium utilizes host oxidative molecules to activate regulatory proteins that enhance the production of effector molecules, counteracting the host weapon NADPH oxidase and inducing a protective response.
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