Phenylalanine and COVID-19: Tracking disease severity markers.
Phenylalanine and COVID-19: Tracking disease severity markers.
复制标题
DOI：
10.1016/j.intimp.2021.108313
复制
发表时间：
2021-12
影响因子：
5.6
通讯作者：
de Freitas Anibal F
中科院分区：
文献类型：
--
作者：
Luporini RL;Pott-Junior H;Di Medeiros Leal MCB;Castro A;Ferreira AG;Cominetti MR;de Freitas Anibal F
尽管有几个预测新冠肺炎严重程度的因素，但没有一个是具体的。近来，在非新冠肺炎患者中，血清苯丙氨酸水平与炎症增加、SOFA评分高、住ICU和死亡率有关。在这里，我们调查了患有新冠肺炎的成年人苯丙氨酸和炎症标志物之间的关系。我们评估了入院时患有新冠肺炎的成年人的临床和实验室数据。核磁共振波谱测定血清苯丙氨酸及其代谢途径的其他氨基酸水平。流式细胞仪检测血清IL-2、IL-4、IL-6、IL-10、肿瘤坏死因子-α和干扰素-γ水平。校正潜在混杂因素的线性回归模型评估了血清苯丙氨酸水平和炎性细胞因子之间的关系。与中度和重度组相比，轻度疾病组的苯丙氨酸和酪氨酸显著降低。线性回归模型显示，无论分析什么细胞因子，在调整潜在混杂因素后，苯丙氨酸与疾病严重程度独立且正相关。此外，轻度病例从发病到入院的前十天内，血清苯丙氨酸水平一直较低。苯丙氨酸是疾病严重程度的标志。这种联系与症状的出现和炎症状态的严重程度之间的时间无关。
Although there are several severity predictors for COVID-19, none are specific. Serum levels of phenylalanine were recently associated with increased inflammation, higher SOFA scores, ICU admission, and mortality rates among non-COVID-19 patients. Here, we investigated the relationship between phenylalanine and inflammatory markers in adults with COVID-19. We assessed adults with COVID-19 at hospital admission for clinical and laboratory data. Nuclear magnetic resonance spectroscopy measured serum levels of phenylalanine and other amino acids of its metabolomic pathway. Flow Cytometry measured serum levels of IL-2, IL-4, IL-6, Il-10, TNF-α, and IFN-γ. Linear regression models adjusted for potential confounders assessed the relationship between serum levels of phenylalanine and inflammatory cytokines. Phenylalanine and tyrosine were significantly lower in mild disease as compared to moderate and severe groups. Linear regression models showed that phenylalanine is independently and positively associated with disease severity regardless of the cytokine analyzed and after adjustment for potential confounders. In addition, mild cases showed consistently lower serum phenylalanine levels within the first ten days from disease onset to hospital admission. Phenylalanine is a marker of disease severity. This association is independent of the time between the onset of symptoms and the magnitude of the inflammatory state.
登录
查看更多内容
影响因子：
5.6
作者：
Delshad M;Tavakolinia N;Pourbagheri-Sigaroodi A;Safaroghli-Azar A;Bagheri N;Bashash D
通讯作者：
Bashash D
影响因子：
4.4
作者：
Lawler, Nathan G.;Gray, Nicola;Nicholson, Jeremy K.
通讯作者：
Nicholson, Jeremy K.
影响因子：
3.7
作者：
Fernández Villalobos NV;Ott JJ;Klett-Tammen CJ;Bockey A;Vanella P;Krause G;Lange B
通讯作者：
Lange B
DOI：
10.4269/ajtmh.20-1110
发表时间：
2020-12
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Kwon JS;Kim JY;Kim MC;Park SY;Kim BN;Bae S;Cha HH;Jung J;Kim MJ;Lee MJ;Choi SH;Chung JW;Shin EC;Kim SH
通讯作者：
Kim SH
影响因子：
11.4
作者：
Chen, Yan-Mei;Zheng, Yuanting;Zhang, Yong-Zhen
通讯作者：
Zhang, Yong-Zhen