Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actions.
Learning substrates in the primate prefrontal cortex and striatum: sustained activity related to successful actions.
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DOI：
10.1016/j.neuron.2009.06.019
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发表时间：
2009-07-30
期刊：
影响因子：
16.2
通讯作者：
Miller, Earl K.
中科院分区：
文献类型：
--
作者：
Histed, Mark H.;Pasupathy, Anitha;Miller, Earl K.
从经验中学习需要知道过去的行动是否产生了预期的结果。前额叶皮质和基底节被认为在这种学习任意刺激-反应联系的过程中发挥关键作用。以前的研究已经发现，这些区域的神经活动类似于短暂反映反应正确或错误的多巴胺能神经元信号。然而，目前尚不清楚这种不到一秒的短暂活动会如何影响随后发生的行动。在这里，我们报告了两个区域单个神经元的持续结果相关反应，这种反应持续几秒钟，直到下一次试验。此外，一次试验的结果会影响下一次试验的神经活动和行为：当上一次试验正确时，行为反应往往是正确的，单个神经元更准确地区分可能的反应。这些关于试验结果的长期信号提供了一种将一个行动与下一个行动联系起来的方法，并可能允许随着时间的推移将奖励信号结合起来，以实现成功的学习。
Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to dopaminergic neuron signals that transiently reflect whether a response is correct or incorrect. However, it is unclear how this transient activity, which fades in under a second, influences actions that occur much later. Here we report sustained outcome-related responses in single neurons of both areas, which last for several seconds until the next trial. Moreover, the outcome on a single trial influences the neural activity and behavior on the next trial: behavioral responses are more often correct and single neurons more accurately discriminate between the possible responses when the previous trial was correct. These long-lasting signals about trial outcome provide a way to link one action to the next, and may allow reward signals to be combined over time to implement successful learning.
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