Evidence for avian influenza A infections among Iowa's agricultural workers.
Evidence for avian influenza A infections among Iowa's agricultural workers.
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DOI：
10.1111/j.1750-2659.2008.00041.x
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发表时间：
2008-03
影响因子：
4.4
通讯作者：
Lynch, Charles F.
中科院分区：
文献类型：
--
作者：
Gray, Gregory C.;McCarthy, Troy;Capuano, Ana W.;Setterquist, Sharon F.;Alavanja, Michael C.;Lynch, Charles F.
关键词：
识别人畜共患流感传播的危险因素可能有助于公共卫生官员制定流感大流行规划。 目的我们试图评估农村爱荷华州农业工人暴露于家禽禽流感病毒感染的证据。 方法2004年，我们在一项为期2年的人畜共患流感传播的前瞻性研究中招募了803名爱荷华州农村成年人。 他们的入组数据和血清与2006年在爱荷华州大学入组的66名成人对照组的数据和血清采用比例优势模型进行比较。 结果803名参与者中58.8%为男性，平均年龄55.6岁。 48%的人报告了以前的家禽暴露。用微量中和技术研究了血清中抗禽H4、H5、H6、H7和H9病毒的抗体。接触活禽与抗H5病毒抗体滴度增加相关（OR 1.2; 95%CI 1.02 - 1.8）。同样，报告狩猎野鸟的受试者对H7病毒的抗体滴度增加（OR 2.8; 95%CI 1.2 - 6.5），报告最近接触家禽的受试者对H6（OR 3.4; 95%CI 1.4 - 8.5）和H7病毒（OR 2.5，95%CI 1.1 - 5.7）的抗体滴度增加。没有证据显示抗H4或H9禽流感病毒的抗体有所增加。 结论这些数据表明，狩猎和接触家禽可能是美国农村人群感染禽流感病毒的重要危险因素。 农业工作者应被纳入流感大流行计划。
Background Identifying risk factors for zoonotic influenza transmission may aid public health officials in pandemic influenza planning. Objectives We sought to evaluate rural Iowan agriculture workers exposed to poultry for previous evidence of avian influenza virus infection. Methods In 2004, we enrolled 803 rural adult Iowans in a 2‐year prospective study of zoonotic influenza transmission. Their enrollment data and sera were compared with those of 66 adult controls enrolled at the University of Iowa in 2006 by using proportional odds modeling. Results Of the 803 participants 58·8% were male with a mean age of 55·6 years. Forty‐eight percent reported previous poultry exposure. Sera were studied by microneutralization techniques for antibodies against avian H4, H5, H6, H7 and H9 viruses. Touching live birds was associated (OR 1·2; 95% CI 1·02–1·8) with increased antibody titer against H5 virus. Similarly, participants who reported hunting wild birds had increased antibody titers against H7 virus (OR 2·8; 95%CI 1·2–6·5) and subjects who reported recent exposure to poultry had increased antibody titers against H6 (OR 3·4; 95% CI 1·4–8·5) and H7 viruses (OR 2·5, 95% CI 1·1–5·7). There was no evidence of elevated antibody against avian H4 or H9 viruses. Conclusions These data suggest that hunting and exposure to poultry may be important risk factors for avian influenza virus infection among rural US populations. Agriculture workers should be included in influenza pandemic plans.
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