Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA).
Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA).
复制标题
DOI：
10.1016/j.maturitas.2016.11.017
复制
发表时间：
2017-02
期刊：
影响因子：
4.9
通讯作者：
Michos ED
中科院分区：
文献类型：
--
作者：
Zhao D;Ouyang P;de Boer IH;Lutsey PL;Farag YM;Guallar E;Siscovick DS;Post WS;Kalyani RR;Billups KL;Michos ED
25-羟基维生素D [25(OH)D]缺乏与男性睾丸激素水平低有关，但其与女性性激素的关系存在相互矛盾的报道。对于这些关联是否独立于肥胖和生活方式因素，以及它们是否因种族/民族而异，我们知之甚少。研究25(OH)D浓度与性激素水平的关系。在一个多种族队列中，3017名男性和2929名女性的横断面分析。睾酮、雌二醇、脱氢表雄酮（DHEA）、性激素结合球蛋白（SHBG）和游离睾酮。男性和女性25(OH)D的平均（SD）水平分别为25.7（10.4）和26.1(12.0)ng/ml。在男性中，在调整人口统计学和生活方式变量后，25(OH)D水平每降低10 ng/ml [25 nmol/L]， SHBG和游离睾酮的平均差异分别为- 0.70 nmol/L （95%CI为- 1.36,- 0.05）和0.02%(0.01,0.04)，但与总睾酮水平低（<10.41 nmol/L）无关。在女性中，25(OH)D水平每降低10 ng/ml，雌二醇的平均差异为- 0.01 nmol/L (- 0.01, - 0.00)， SHBG的平均差异为- 8.29 nmol/L(- 10.13, - 6.45)，游离睾酮的平均差异为0.06% (0.04,0.07)，DHEA的平均差异为0.40 nmol/L（0.19, 0.62）。种族/民族之间没有显著的相互作用。较低的25(OH)D浓度与男性和女性较低的SHBG水平和较高的游离睾酮水平以及女性较低的雌二醇和较高的脱氢表雄酮水平有关，与肥胖和生活方式无关。我们观察到25(OH)D与男性总睾酮无显著关联。需要进一步的研究来确定补充维生素D是否会影响性激素水平。在一项对3017名男性和2931名女性的多种族队列横断面分析中，较低的维生素D水平[每10 ng/ml （25 nmol/L）较低的25(OH)D]与男性和女性较低的SHBG和较高的游离睾酮有关，与女性较低的雌二醇和较高的脱氢表雄酮有关，与肥胖和生活方式因素无关。需要进一步的研究来确定补充维生素D是否会影响性激素水平
25-hydroxyvitamin D [25(OH)D] deficiency has been associated with low testosterone levels in men, but there are conflicting reports of its associations with sex hormones in women. Less is known about whether these associations are independent of adiposity and lifestyle factors, and whether they differ by race/ethnicity. To examine associations of 25(OH)D concentrations with sex hormone levels. Cross-sectional analysis of 3017 men and 2929 women in a multi-ethnic cohort. Testosterone, estradiol, dehydroepiandrosterone (DHEA), sex hormone binding globulin (SHBG), and free testosterone. The mean (SD) levels of 25(OH)D in men and women were 25.7(10.4) and 26.1(12.0) ng/ml, respectively. In men, after adjusting for demographic and lifestyle variables, a 10 ng/ml [25 nmol/L] decrease in 25(OH)D was associated with an average difference of −0.70 nmol/L (95%CI −1.36, −0.05) in SHBG and 0.02 percent (0.01, 0.04) in free testosterone, but was not associated with low total testosterone level (<10.41 nmol/L). In women, a 10 ng/ml decrease in 25(OH)D levels was associated with an average difference of −0.01 nmol/L (−0.01, −0.00) for estradiol, −8.29 nmol/L (−10.13, −6.45) for SHBG, 0.06 percent (0.04, 0.07) for free testosterone, and 0.40 nmol/L (0.19, 0.62) for DHEA. There was no significant interaction by race/ethnicity. Lower 25(OH)D concentrations were associated with lower SHBG levels and higher free testosterone levels in both men and women, and lower estradiol and higher DHEA levels in women, independent of adiposity and lifestyle. We observed no significant association of 25(OH)D with total testosterone in men. Future studies are needed to determine whether vitamin D supplementation influences sex hormone levels. In a cross-sectional analysis of 3017 men and 2931 women in a multi-ethnic cohort, lower vitamin D levels [per 10 ng/ml (25 nmol/L) lower 25(OH)D] were associated with lower SHBG and higher free testosterone in both men and women, and lower estradiol and higher DHEA in women, independent of adiposity and lifestyle factors. Future studies are needed to determine whether vitamin D supplementation influences sex hormone levels
登录
查看更多内容
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
2.6
作者：
Dandona P;Rosenberg MT
通讯作者：
Rosenberg MT
影响因子：
2.2
作者：
Jorde, R.;Grimnes, G.;Svartberg, J.
通讯作者：
Svartberg, J.
影响因子：
5.8
作者：
Hofer, D.;Muenzker, J.;Obermayer-Pietsch, B.
通讯作者：
Obermayer-Pietsch, B.
影响因子：
5.8
作者：
Berman, DM;Rodrigues, LM;Goldberg, AP
通讯作者：
Goldberg, AP