Smoking and perceived stress in relation to short salivary telomere length among caregivers of children with disabilities.
Smoking and perceived stress in relation to short salivary telomere length among caregivers of children with disabilities.
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DOI：
10.3109/10253890.2014.969704
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Williams MA
中科院分区：
文献类型：
--
作者：
Chen X;Velez JC;Barbosa C;Pepper M;Andrade A;Stoner L;De Vivo I;Gelaye B;Williams MA
端粒长度（TL）是在染色体末端形成保护帽的DNA重复序列的长度，已成为细胞衰老和氧化应激的新生物标志物。越来越多的研究探讨吸烟和感知压力与TL的关系，结果不一致。本研究旨在探讨吸烟和感知压力是否与残疾儿童主要照顾者唾液TL缩短有关。使用定量聚合酶链反应方法，唾液TL进行了评估，89名照顾者，年龄在19-69岁（87%是妇女），谁照顾残疾儿童在巴塔哥尼亚地区，智利。访谈管理的问卷被用来收集社会人口和生活方式行为的信息。14项感知压力量表被用来评估感知压力。平均相对TL为0.92（标准误=0.03）。吸烟者的年龄校正平均TL比不吸烟者低0.07个单位（β =-0.07，标准误=0.03; p=0.012）。在调整了年龄和感知压力后，吸烟者的TL（<0.73，TL的最低四分位数）比不吸烟者短的可能性高2.17倍（比值比=3.17; 95%置信区间=1.05-9.52）。在调整年龄和吸烟因素后，感知压力较高的照顾者的TL较短的可能性是感知压力较低的照顾者的2.13倍（比值比=3.13; 95%置信区间=1.03-9.55）。这项研究提供了第一个证据表明，吸烟和感知压力之间的强关联和缩短唾液TL照顾残疾儿童。更大规模的关于吸烟状况的详细信息的研究是必要的，以证实我们的发现。
Telomere length (TL), the length of repeated DNA sequence that forms protective caps at the end of chromosomes, has emerged as a novel biomarker of cell aging and oxidative stress. There is increasing research exploring the associations of smoking and perceived stress with TL, and the results are inconsistent. This study aimed to examine whether smoking and perceived stress were associated with shortened salivary TL among primary caregivers of children with disabilities. Using a quantitative polymerase chain reaction method, salivary TL was assessed among 89 caregivers aged 19–69 years (87% were women) who took care of disabled children in the Patagonia Region, Chile. Interviewer-administered questionnaires were used to collect information on sociodemographic and lifestyle behaviors. The 14-item Perceived Stress Scale was used to assess perceived stress. Mean relative TL was 0.92 (standard error=0.03). Smokers had age-adjusted mean TL that was 0.07 units lower (beta=−0.07, standard error=0.03; p=0.012) than non-smokers. Smokers were 2.17 times more likely to have shorter TL (<0.73, the lowest quartile of TL) than non-smokers (odds ratio =3.17; 95% confidence interval=1.05–9.52) with adjustment for age and perceived stress. Caregivers with higher perceived stress were 2.13 times more likely to have shorter TL (odds ratio=3.13; 95% confidence interval=1.03–9.55) than caregivers with lower perceived stress after adjustment for age and smoking. This study provides the first evidence of strong associations between smoking and perceived stress and shortened salivary TL among caregivers of children with disabilities. Larger studies with detailed information on smoking status are warranted to confirm our findings.
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