Magnetic nanoformulations for prostate cancer.

Magnetic nanoformulations for prostate cancer.
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前列腺癌的磁纳米制剂。

DOI:
10.1016/j.drudis.2017.04.018
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发表时间:
2017-08
影响因子:
7.4
通讯作者:
Yallapu MM
Yallapu MM
中科院分区:
医学2区
文献类型:
--
作者:
Chowdhury P;Roberts AM;Khan S;Hafeez BB;Chauhan SC;Jaggi M;Yallapu MM

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磁性纳米颗粒(MNP)在改善成像应用方面发挥着至关重要的作用。近年来,许多研究表明,纳米粒可用于靶向给药、药物缓释和热疗。基于稳定的颗粒尺寸和形状、生物相容性和固有的对比增强特性,MNP已被鼓励用于临床前研究和人类使用。作为一个治疗诊断平台的发展,MNP需要平衡交付和成像方面。因此,本综述通过记录用于前列腺癌的独特磁性纳米颗粒、其与前列腺癌细胞的相互作用、体内命运、靶向和生物分布,提供了对MNP治疗诊断作用的重要见解和进展。各种新型纳米制剂在前列腺癌的具体和定制的应用进行了讨论。
Magnetic nanoparticles (MNPs) play a vital role for improved imaging applications. Recently, a number of studies demonstrate MNPs can be applied for targeted delivery, sustained release of therapeutics, and hyperthermia. Based on stable particle size and shape, biocompatibility, and inherent contrast enhancement characteristics, MNPs have been encouraged for pre-clinical studies and human use. As a theranostic platform development, MNPs need to balance both delivery and imaging aspects. Thus, this review provides significant insight and advances in the theranostic role of MNPs through the documentation of unique magnetic nanoparticles used in prostate cancer, their interaction with prostate cancer cells, in vivo fate, targeting, and biodistribution. Specific and custom-made applications of various novel nanoformulations in prostate cancer are discussed.
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