iDQC anisotropy map imaging for tumor tissue characterization in vivo.

iDQC anisotropy map imaging for tumor tissue characterization in vivo.
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DOI:
10.1002/mrm.21925
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发表时间:
2009-04
影响因子:
3.3
通讯作者:
Warren WS
Warren WS
中科院分区:
医学3区
文献类型:
--
作者:
Branca RT;Chen YM;Mouraviev V;Galiana G;Jenista ER;Kumar C;Leuschner C;Warren WS

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分子间双量子相干(iDQC),由两个或更多个分离的自旋的同时跃迁产生的信号,已知产生对亚体素结构,特别是局部各向异性高度敏感的图像。在这里,我们展示了如何iDQC信号可以用于有效地检测乳腺肿瘤组织和前列腺肿瘤组织中产生的各向异性的靶向(LHRH共轭)超顺磁性纳米粒子(SPION),从而区分坏死区域从周围的肿瘤组织。
Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagentic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.
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