The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors.
The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors.
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在代谢途径中发现了许多活性中间体。这些潜在的有毒分子能被利用来造福于生物体吗？我们认为，在某些微生物感染期间，受感染的宿主产生固有的反应性醛是一种以前未被认识的先天免疫防御机制。虽然醛对哺乳动物生理的影响一直是人们关注的焦点，但关于醛可能被利用或被故意诱导来杀死病原体的想法是新的。鉴于醛是作为新陈代谢程序的一部分，伴随着细胞因子干扰素-γ在感染期间激活免疫细胞，我们假设醛是病原体控制所需的干扰素-γ诱导的效应物之一。
There are many reactive intermediates found in metabolic pathways. Could these potentially toxic molecules be exploited for an organism's benefit? We propose that during certain microbial infections, the production of inherently reactive aldehydes by an infected host is a previously unappreciated innate immune defence mechanism. While there has been a significant focus on the effects of aldehydes on mammalian physiology, the idea that they might be exploited or purposefully induced to kill pathogens is new. Given that aldehydes are made as parts of metabolic programmes that accompany immune cell activation by the cytokine interferon-gamma (IFN-γ) during infections, we hypothesize that aldehydes are among the arsenal of IFN-γ-inducible effectors needed for pathogen control.
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