China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis.
China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis.
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中国结核病流行源于结核分枝杆菌四种菌株的历史性扩张
DOI：
10.1038/s41559-018-0680-6
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发表时间：
2018-12
影响因子：
16.8
通讯作者：
Gao Q
中科院分区：
文献类型：
--
作者：
Liu Q;Ma A;Wei L;Pang Y;Wu B;Luo T;Zhou Y;Zheng HX;Jiang Q;Gan M;Zuo T;Liu M;Yang C;Jin L;Comas I;Gagneux S;Zhao Y;Pepperell CS;Gao Q
少数高负担国家占全世界结核病病例的大多数。缺乏这些地区的详细数据。为了探讨M.在中国这个结核病负担第三高的国家，我们分析了全国范围内收集的4,578个分离株。大粒M.中国结核菌群中，99.4%的细菌群属于谱系2和谱系4的三个亚系。这四种基因型根深蒂固的系统发育位置和地理限制表明，它们的种群在少量引入中国后就地扩大。合并分析表明，这些细菌亚群大约在1,000年前出现在中国，从12世纪开始平行扩张，整个种群在18世纪晚期达到顶峰。最近，亚系L2.3，这是中国本土的，并表现出相对较高的传播性和广泛的全球传播，来主导的人口动态的M。肺结核在中国我们的研究结果表明，四个M。结核分枝杆菌菌株塑造了中国目前的结核病流行，并强调了土著结核分枝杆菌的长期遗传连续性。结核病人口。
A small number of high-burden countries account for the majority of tuberculosis cases worldwide. Detailed data are lacking from these regions. To explore the evolutionary history of M. tuberculosis in China — the third highest TB burden country — we analyzed a countrywide collection of 4,578 isolates. Little genetic diversity was detected within the large M. tuberculosis population in China, with 99.4% of the bacterial population belonging to lineage 2 and three sublineages of lineage 4. The deeply rooted phylogenetic positions and geographic restriction of these four genotypes indicate that their populations expanded in situ following a small number of introductions to China. Coalescent analyses suggest that these bacterial sub-populations emerged in China around 1,000 years ago, expanded in parallel from the 12th century onward, and the whole population peaked in the late 18th century. More recently, sublineage L2.3, which is indigenous to China and exhibited relatively high transmissibility and extensive global dissemination, came to dominate the population dynamics of M. tuberculosis in China. Our results indicate that historical expansion of four M. tuberculosis strains shaped the current TB epidemic in China, and highlight the long-term genetic continuity of the indigenous M. tuberculosis population.
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影响因子：
64.8
作者：
Bos KI;Harkins KM;Herbig A;Coscolla M;Weber N;Comas I;Forrest SA;Bryant JM;Harris SR;Schuenemann VJ;Campbell TJ;Majander K;Wilbur AK;Guichon RA;Wolfe Steadman DL;Cook DC;Niemann S;Behr MA;Zumarraga M;Bastida R;Huson D;Nieselt K;Young D;Parkhill J;Buikstra JE;Gagneux S;Stone AC;Krause J
通讯作者：
Krause J
影响因子：
30.8
作者：
Holt KE;McAdam P;Thai PVK;Thuong NTT;Ha DTM;Lan NN;Lan NH;Nhu NTQ;Hai HT;Ha VTN;Thwaites G;Edwards DJ;Nath AP;Pham K;Ascher DB;Farrar J;Khor CC;Teo YY;Inouye M;Caws M;Dunstan SJ
通讯作者：
Dunstan SJ
DOI：
10.1073/pnas.0914274108
发表时间：
2011-04-12
影响因子：
11.1
作者：
Gignoux, Christopher R.;Henn, Brenna M.;Mountain, Joanna L.
通讯作者：
Mountain, Joanna L.
影响因子：
28.3
作者：
Ates, Louis S.;Dippenaar, Anzaan;Bitter, Wilbert
通讯作者：
Bitter, Wilbert
影响因子：
3.7
作者：
Comas I;Homolka S;Niemann S;Gagneux S
通讯作者：
Gagneux S