Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.
Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.
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DOI：
10.1016/j.phrs.2018.03.020
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发表时间：
2018-06
影响因子：
9.3
通讯作者：
Margolis KG
中科院分区：
文献类型：
--
作者：
Israelyan N;Margolis KG
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是社会沟通和重复行为模式的持续缺陷。然而，ASD通常与医学合并症相关，并且胃肠道（GI）功能障碍是最常见的。研究表明，ASD患者的GI功能障碍与社交障碍程度之间存在相关性。ASD中GI异常的病因尚不清楚，尽管GI功能障碍与ASD相关行为之间的关联表明，脑和肠中的重叠发育缺陷和/或肠和中枢神经系统（分别为ENS和CNS）之间的通信缺陷（称为肠-脑轴）可能是观察到的表型的原因。脑肠异常越来越多地与包括ASD在内的几种疾病过程有关。5-羟色胺作为ENS和CNS发育和功能的关键调节剂，可能是ASD中肠-脑轴的联系。本文从ENS的角度综述了5-羟色胺在ASD中的作用。一种小鼠模型已被证明具有模拟ASD中所见的脑、行为和GI异常，该模型含有在ASD儿童中发现的最常见的基于5-羟色胺转运体（SERT）的突变（SERT Ala56）。讨论的肠-脑的表现在SERT的Ala56小鼠，和他们的纠正与发展管理的5-HT4激动剂，也解决了与其他未来的诊断和治疗方向。
Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a correlation between GI dysfunction and the degree of social impairment in ASD. The etiology of GI abnormalities in ASD is unclear, though the association between GI dysfunction and ASD-associated behaviors suggest that overlapping developmental defects in the brain and the intestine and/or a defect in communication between the enteric and central nervous systems (ENS and CNS, respectively), known as the gut-brain axis, could be responsible for the observed phenotypes. Brain-gut abnormalities have been increasingly implicated in several disease processes, including ASD. As a critical modulator of ENS and CNS development and function, serotonin may be a nexus for the gut-brain axis in ASD. This paper reviews the role of serotonin in ASD from the perspective of the ENS. A murine model that has been demonstrated to possess brain, behavioral and GI abnormalities mimicking those seen in ASD harbors the most common serotonin transporter (SERT) based mutation (SERT Ala56) found in children with ASD. Discussion of the gut-brain manifestations in the SERT Ala56 mice, and their correction with developmental administration of a 5-HT4 agonist, are also addressed in conjunction with other future directions for diagnosis and treatment.
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影响因子：
11.1
作者：
Golubeva AV;Joyce SA;Moloney G;Burokas A;Sherwin E;Arboleya S;Flynn I;Khochanskiy D;Moya-Pérez A;Peterson V;Rea K;Murphy K;Makarova O;Buravkov S;Hyland NP;Stanton C;Clarke G;Gahan CGM;Dinan TG;Cryan JF
通讯作者：
Cryan JF
影响因子：
9.1
作者：
Ashwood, P;Anthony, A;Wakefield, AJ
通讯作者：
Wakefield, AJ
影响因子：
3.9
作者：
Esbensen, Anna J.;Greenberg, Jan S.;Seltzer, Marsha Mailick;Aman, Michael G.
通讯作者：
Aman, Michael G.
影响因子：
3.5
作者：
Gershon, M. D.;Liu, M.-T.
通讯作者：
Liu, M.-T.
DOI：
10.1097/med.0b013e32835bc703
发表时间：
2013-02
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Gershon MD
通讯作者：
Gershon MD