Herb-herb combination for therapeutic enhancement and advancement: theory, practice and future perspectives.
Herb-herb combination for therapeutic enhancement and advancement: theory, practice and future perspectives.
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治疗性增强和进步的草药结合：理论，实践和未来观点。
DOI：
10.3390/molecules18055125
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发表时间：
2013-05-03
期刊：
影响因子：
--
通讯作者：
Lam CW
中科院分区：
文献类型：
--
作者：
Che CT;Wang ZJ;Chow MS;Lam CW
草药组合已经在中医实践中使用了数千年，但缺乏科学证据证明其治疗效果。随着人们越来越有兴趣从一药一靶范式转向联合疗法或多种药物以实现对一些疾病的治疗效益，有动力通过利用草药组合的过去经验来探索新知识。本文综述了中药配伍的传统概念和实践，并强调了现有的科学和临床证据，以支持中药的联合使用。希望这些信息将为开发未来治疗进展和药物产品开发的新方法提供线索。很可能，现代技术与草药产品质量控制、活性成分鉴定和分子机制理解的创新研究相结合，再加上精心设计的动物和临床研究，将为丰富的经验知识铺平道路，从草药-草药组合到新的治疗方式。
Herb-herb combinations have been used in Chinese medicine practice for thousands of years, yet scientific evidence of their therapeutic benefits is lacking. With increasing interest in shifting from the one-drug-one-target paradigm to combination therapy or polypharmacy to achieve therapeutic benefits for a number of diseases, there is momentum to explore new knowledge by tapping the past empirical experiences of herb-herb combinations. This review presents an overview of the traditional concept and practice of herb-herb combination in Chinese medicine, and highlights the available scientific and clinical evidence to support the combined use of herbs. It is hoped that such information would provide a lead for developing new approaches for future therapeutic advancement and pharmaceutical product development. Very likely modern technologies combined with innovative research for the quality control of herbal products, identification of active components and understanding of the molecular mechanism, followed by well-designed animal and clinical studies would pave the way in advancing the wealth of empirical knowledge from herb-herb combination to new therapeutic modalities.
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