Self-organized stress patterns drive state transitions in actin cortices.
Self-organized stress patterns drive state transitions in actin cortices.
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DOI：
10.1126/sciadv.aar2847
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发表时间：
2018-06
期刊：
影响因子：
13.6
通讯作者：
Fakhri N
中科院分区：
文献类型：
--
作者：
Tan TH;Malik-Garbi M;Abu-Shah E;Li J;Sharma A;MacKintosh FC;Keren K;Schmidt CF;Fakhri N
网络渗透和肌球蛋白产生的应力传播之间的相互作用导致了皮质中动态不同的稳定状态。生物功能依赖于有序的结构和复杂控制的集体动力学。生命系统中的这种秩序通常是通过能量的持续耗散来建立和维持的。集体运动模式的出现是非平衡系统所特有的，是动态稳态的一种表现。动物细胞的机械弹性在很大程度上是由肌动球蛋白皮层控制的。皮质提供稳定性，但同时由于其成分的快速周转而具有高度适应性。动态功能涉及皮层不同稳态之间的调节转换。我们发现，模型肌动球蛋白皮质，构造，以保持营业额，自组织成不同的非平衡稳态时，我们改变交联密度。肌动蛋白网络结构和产生应力的肌球蛋白马达组织之间的反馈定义了动态稳态的对称性。轻微交联状态显示无发散的远程流动模式。较高的交联密度导致结构对称性破坏，从而导致稳定的会聚流型。我们使用荧光单壁碳纳米管作为新型探针跟踪模型肌动球蛋白皮质中的流动模式。我们在模型系统中观察到的压力模式的自组织可以对生物功能产生直接影响。
The interplay between network percolation and myosin-generated stress propagation leads to dynamically distinct steady states in cortices. Biological functions rely on ordered structures and intricately controlled collective dynamics. This order in living systems is typically established and sustained by continuous dissipation of energy. The emergence of collective patterns of motion is unique to nonequilibrium systems and is a manifestation of dynamic steady states. Mechanical resilience of animal cells is largely controlled by the actomyosin cortex. The cortex provides stability but is, at the same time, highly adaptable due to rapid turnover of its components. Dynamic functions involve regulated transitions between different steady states of the cortex. We find that model actomyosin cortices, constructed to maintain turnover, self-organize into distinct nonequilibrium steady states when we vary cross-link density. The feedback between actin network structure and organization of stress-generating myosin motors defines the symmetries of the dynamic steady states. A marginally cross-linked state displays divergence-free long-range flow patterns. Higher cross-link density causes structural symmetry breaking, resulting in a stationary converging flow pattern. We track the flow patterns in the model actomyosin cortices using fluorescent single-walled carbon nanotubes as novel probes. The self-organization of stress patterns we have observed in a model system can have direct implications for biological functions.
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影响因子：
64.8
作者：
Martin, Adam C.;Kaschube, Matthias;Wieschaus, Eric F.
通讯作者：
Wieschaus, Eric F.
影响因子：
13.6
作者：
Fritzsche M;Erlenkämper C;Moeendarbary E;Charras G;Kruse K
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Kruse K
影响因子：
3.4
作者：
Bruinsma, Robijn;Grosberg, Alexander Y.;Zidovska, Alexandra
通讯作者：
Zidovska, Alexandra
影响因子：
3.4
作者：
Charras, Guillaume T.;Coughlin, Margaret;Mahadevan, L.
通讯作者：
Mahadevan, L.
影响因子：
44.1
作者：
Marchetti, M. C.;Joanny, J. F.;Simha, R. Aditi
通讯作者：
Simha, R. Aditi