Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers.
Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers.
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DOI：
10.1038/s41598-017-13802-5
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发表时间：
2017-10-16
影响因子：
4.6
通讯作者：
St-Pierre Y
中科院分区：
文献类型：
--
作者：
Labrie M;De Araujo LOF;Communal L;Mes-Masson AM;St-Pierre Y
半乳糖凝集素在检测癌细胞中糖基化畸变方面越来越接近中心阶段。在这里，我们研究了半乳糖凝集素在卵巢癌（OC）中的表达，并研究了它们作为高级别浆液性卵巢癌（HGSC）患者组织和血浆样本中生物标志物的潜力。在组织中，我们发现基质gal-1和上皮gal-8/9的蛋白表达增加与HGSC患者对治疗的不良反应相关。Gal-8/9分别是化疗耐药性和总生存期（OS）的独立预测因子。这种半乳糖凝集素特征增加了癌抗原125（CA 125）对5年无病生存期（DFS）、化疗后治疗和5年OS的预测价值。在CA 125 LOW患者中，上皮gal-9与较低的5年OS相关，而基质gal-1和上皮gal-8均与较低的5年DFS相关。使用血浆样品也发现了gal-8和gal-9的这种阴性预测值。在这两种情况下，gal-8和gal-9的高血浆水平与较低的OS和DFS相关。总之，这些数据表明，半乳糖凝集素可能是有前途的生物标志物，以确定亚组的HGSC患者预后较差。我们的研究也有助于更好地定义疾病的异质性。
Galectins are moving closer to center stage in detecting glycosylation aberration in cancer cells. Here, we have investigated the expression of galectins in ovarian cancer (OC) and examined their potential as biomarkers in tissues and blood plasma samples of high grade serous ovarian carcinoma (HGSC) patients. In tissues, we found that increased protein expression of stromal gal-1 and epithelial gal-8/9 was associated with a poor response to treatment of HGSC patients. Gal-8/9 were both independent predictors of chemoresistance and overall survival (OS), respectively. This galectin signature increased the predictive value of the cancer antigen 125 (CA125) on 5-year disease-free survival (DFS), post-chemotherapy treatment and 5-year OS. In CA125LOW patients, epithelial gal-9 was associated with a lower 5-year OS while stromal gal-1 and epithelial gal-8 were both associated with a lower 5-year DFS. Such negative predictive value of gal-8 and gal-9 was also found using plasma samples. In both cases, high plasma levels of gal-8 and gal-9 was associated with a lower OS and DFS. Overall, these data suggest that galectins may be promising biomarkers to identify subgroups of HGSC patients with poorer prognosis. Our study also contributes to better define the heterogeneity of the disease.
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影响因子：
7.2
作者：
Compagno D;Laderach DJ;Gentilini L;Jaworski FM;Rabinovich GA
通讯作者：
Rabinovich GA
影响因子：
8.8
作者：
Chagan-Yasutan, Haorile;Ndhlovu, Lishomwa C.;Lacuesta, Talitha Lea;Kubo, Toru;Leano, Prisca Susan A.;Niki, Toshiro;Oguma, Shigeru;Morita, Kouichi;Chew, Glen. M.;Barbour, Jason D.;Telan, Elizabeth Freda O.;Hirashima, Mitsuomi;Hattori, Toshio;Dimaano, Efren M.
通讯作者：
Dimaano, Efren M.
影响因子：
9.3
作者：
Fredriksson, Simon;Horecka, Joe;Davis, Ronald W.
通讯作者：
Davis, Ronald W.
影响因子：
37.3
作者：
Felder M;Kapur A;Gonzalez-Bosquet J;Horibata S;Heintz J;Albrecht R;Fass L;Kaur J;Hu K;Shojaei H;Whelan RJ;Patankar MS
通讯作者：
Patankar MS
DOI：
10.1097/igc.0000000000000908
发表时间：
2017-03-01
影响因子：
4.8
作者：
Cho, Hye-yon;Kim, Kidong;No, Jae Hong
通讯作者：
No, Jae Hong