Expression and prognostic significance of lysozyme in male breast cancer.
Expression and prognostic significance of lysozyme in male breast cancer.
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DOI：
10.1186/bcr537
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Medrano J
中科院分区：
文献类型：
--
作者：
Serra C;Vizoso F;Alonso L;Rodríguez JC;González LO;Fernández M;Lamelas ML;Sánchez LM;García-Muñiz JL;Baltasar A;Medrano J
溶菌酶是人乳中的主要蛋白质成分之一，也由相当大比例的乳腺癌合成，与女性乳腺癌中具有良好结果的病变相关。本文旨在探讨溶菌酶在男性乳腺癌（MBC）中的表达及其预后价值。用免疫组化方法检测了60例乳腺癌组织切片和15例男性乳房发育症患者的溶菌酶表达。使用HSCORE（组织学评分）系统对染色进行定量，该系统考虑了每种强度下细胞染色的强度和百分比。结合常规预后因素，采用多因素分析回顾性评价溶菌酶的预后价值。所有男性乳房发育症患者的溶菌酶免疫染色均为阴性。60个MBC切片中共有27个（45%）对此蛋白质呈阳性染色，但它们之间在染色细胞的强度和百分比方面存在明显差异。统计学分析显示，溶菌酶HSCORE值与年龄、肿瘤大小、淋巴结状态、组织学分级、雌激素受体状态、转移和组织学类型的关系无统计学意义。单变量分析证实淋巴结受累和溶菌酶值是短期无复发生存率的重要预测因子。根据考克斯回归模型进行的多变量分析也表明，淋巴结状态和溶菌酶水平是短期无复发生存率的重要独立指标。溶菌酶的肿瘤表达与男性乳腺癌中具有不利结果的病变相关。这种乳蛋白可能是乳腺癌患者的一个新的预后因素。
Lysozyme, one of the major protein components of human milk that is also synthesized by a significant percentage of breast carcinomas, is associated with lesions that have a favorable outcome in female breast cancer. Here we evaluate the expression and prognostic value of lysozyme in male breast cancer (MBC). Lysozyme expression was examined by immunohistochemical methods in a series of 60 MBC tissue sections and in 15 patients with gynecomastia. Staining was quantified using the HSCORE (histological score) system, which considers both the intensity and the percentage of cells staining at each intensity. Prognostic value of lysozyme was retrospectively evaluated by multivariate analysis taking into account conventional prognostic factors. Lysozyme immunostaining was negative in all cases of gynecomastia. A total of 27 of 60 MBC sections (45%) stained positively for this protein, but there were clear differences among them with regard to the intensity and percentage of stained cells. Statistical analysis showed that lysozyme HSCORE values in relation to age, tumor size, nodal status, histological grade, estrogen receptor status, metastasis and histological type did not increase the statistical significance. Univariate analysis confirmed that both nodal involvement and lysozyme values were significant predictors of short-term relapse-free survival. Multivariate analysis, according to Cox's regression model, also showed that nodal status and lysozyme levels were significant independent indicators of short-term relapse-free survival. Tumor expression of lysozyme is associated with lesions that have an unfavorable outcome in male breast cancer. This milk protein may be a new prognostic factor in patients with breast cancer.
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影响因子：
3.7
作者：
MANTEL, N;MYERS, M
通讯作者：
MYERS, M
影响因子：
3.8
作者：
PETRAKIS, NL
通讯作者：
PETRAKIS, NL
影响因子：
3.1
作者：
BIGGAR, WD;STURGESS, JM
通讯作者：
STURGESS, JM
影响因子：
5.8
作者：
Touraine, P;Martini, JF;Kelly, PA
通讯作者：
Kelly, PA
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P