Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys.
Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys.
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DOI：
10.1016/j.heares.2022.108568
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发表时间：
2022-10
期刊：
影响因子：
2.8
通讯作者：
Ramachandran, Ramnarayan
中科院分区：
文献类型：
--
作者：
Stahl, Amy N.;Mondul, Jane A.;Alek, Katy A.;Hackett, Troy A.;Ramachandran, Ramnarayan
关键词：
临床听觉生理测量（例如听觉脑干反应，ABR 和失真产物耳声发射，DPOAE）为显性听力损伤的鉴别诊断提供了特异性，但它们检测特定病变部位和细微程度的耳蜗损伤的能力仍然有限。动物模型研究可能是改善鉴别诊断的关键，因为能够诱导严格控制和组织学可验证的亚临床耳蜗病理。在这里，我们使用在一大群雄性猕猴中测量的 ABR 和 DPOAE 提出了一套规范的传统和临床新颖的生理测量方法。鉴于猕猴和人类听觉解剖学、生理学以及对听力损伤的易感性之间的高度相似性，该规范数据集将作为研究新的生理措施以改进诊断的重要基线。 DPOAE 振幅在 f2 = 1.22、L1/L2 = 65/55 时表现稳健，随着频率增加至 10 kHz，并表现出较高的测试重测可靠性。 DPOAE 阈值最低为 2-10 kHz，最高为 < 2 kHz。具有标准临床电极蒙太奇（顶点到乳突，VM）的 ABR 产生的波 I-IV 具有较少观察到的波 I 和较低的阈值。具有顶点到鼓膜 (VT) 电极蒙太奇的 ABR 产生了更强大的 Wave-I，但缺乏 Waves II-IV 和更高的阈值。对 VM 蒙太奇的进一步研究揭示了振幅随着刺激水平的增加而增加，并且在响应点击刺激时最大，其中 Wave-II 显示最大的 ABR 振幅，其次是 -IV 和 -I，具有较高的受试者间和受试者内变异性。 ABR 波潜伏期随着刺激水平和频率的增加而降低。当刺激呈现率增加或刺激在时间上非常接近时，ABR 幅度降低，潜伏期增加。这些发现扩展了非人类灵长类动物规范临床生理数据的现有文献，并为未来研究噪声引起的猕猴病理影响的研究奠定了基础。
Clinical auditory physiological measures (e.g., auditory brainstem responses, ABRs, and distortion product otoacoustic emissions, DPOAEs) provide diagnostic specificity for differentially diagnosing overt hearing impairments, but they remain limited in their ability to detect specific sites of lesion and subtle levels of cochlear damage. Studies in animal models may hold the key to improve differential diagnosis due to the ability to induce tightly controlled and histologically verifiable subclinical cochlear pathologies. Here, we present a normative set of traditional and clinically novel physiological measures using ABRs and DPOAEs measured in a large cohort of male macaque monkeys. Given the high similarities between macaque and human auditory anatomy, physiology, and susceptibility to hearing damage, this normative data set will serve as a crucial baseline to investigate novel physiological measures to improve diagnostics. DPOAE amplitudes were robust at f2 = 1.22, L1/L2 = 65/55, increased with frequency up to 10 kHz, and exhibited high test re-test reliability. DPOAE thresholds were lowest from 2-10 kHz and highest < 2 kHz. ABRs with a standard clinical electrode montage (vertex-to-mastoid, VM) produced Waves I-IV with a less frequently observed Wave-I, and lower thresholds. ABRs with a vertex-to-tympanic membrane (VT) electrode montage produced a more robust Wave-I, but absent Waves II-IV and higher thresholds. Further study with the VM montage revealed amplitudes that increased with stimulus level and were largest in response to click stimuli, with Wave-II showing the largest ABR amplitude, followed by -IV and -I, with high inter- and intra-subject variability. ABR wave latencies decreased with stimulus level and frequency. When stimulus presentation rate increased or stimuli were presented in close temporal proximity, ABR amplitude decreased, and latency increased. These findings expand upon existing literature of normative clinical physiological data in nonhuman primates and lay the groundwork for future studies investigating the effects of noise-induced pathologies in macaques.
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影响因子：
2.4
作者：
Burkard, R;McGee, J;Walsh, EJ
通讯作者：
Walsh, EJ
影响因子：
56.9
作者：
BUCHWALD, JS;HUANG, CM
通讯作者：
HUANG, CM
影响因子：
4.6
作者：
BOSTON, JR
通讯作者：
BOSTON, JR
DOI：
10.3109/01050398309076222
发表时间：
1983-01-01
期刊：
SCANDINAVIAN AUDIOLOGY
影响因子：
--
作者：
CASHMAN, MZ;ROSSMAN, RN
通讯作者：
ROSSMAN, RN
影响因子：
3.3
作者：
Bharadwaj, Hari M.;Mai, Alexandra R.;Shinn-Cunningham, Barbara G.
通讯作者：
Shinn-Cunningham, Barbara G.