Vitamin D concentrations in familial combined hyperlipidemia: effects of lipid lowering treatment.
Vitamin D concentrations in familial combined hyperlipidemia: effects of lipid lowering treatment.
复制标题
DOI：
10.1186/1758-5996-6-7
复制
发表时间：
2014-01-22
影响因子：
4.8
通讯作者：
Pérez A
中科院分区：
文献类型：
--
作者：
Miñambres I;Sánchez-Quesada JL;Sánchez-Hernández J;Rodríguez J;de Leiva A;Pérez A
Vitamin D deficiency has been linked to several cardiovascular risk factors but information regarding vitamin D concentrations in familial combined hyperlipidemia (FCHL) is lacking. Our objective was to examine vitamin D concentrations in patients with FCHL and to study the effects of lipid-lowering therapy. We conducted a cross sectional study on 59 patients with FCHL and 48 healthy controls. We analyzed 25-hydroxyvitamin D (25(OH)D) concentrations and their association with lipid parameters, anthropometric measures, C-reactive protein and homeostasis model assessment (HOMA) index. Twenty-three patients with FCHL were also included in a longitudinal study conducted to analyze 25-hydroxyvitamin D concentrations before and after treatment for dyslipidemia. After adjustment for body mass index and seasonality, patients with FCHL had lower vitamin D concentrations than controls. Adjusted means (standard error of the mean (S.E.M)) for 25(OH)D according to the presence or absence of FCHL were 62.8 (3.6) nmol/L for patients with FCHL and 74.8 (4.1) nmol/L for controls (p = 0.021). In FCHL, hypovitaminosis D was associated with features of atherogenic dyslipidemia. After lipid-lowering therapy, vitamin D concentrations increased (51.0 ± 31.3 to 58.9 ± 24.6 nmol/L (P = 0.022)). However, changes in 25(OH)D concentrations did not correlate with changes in other parameters. Our findings suggest that FCHL is associated with decreased vitamin D concentrations and that treatment for dyslipidemia improves vitamin D status through an unknown mechanism. Further studies are needed to replicate these data in larger populations and to elucidate the mechanisms involved in this association.
登录
查看更多内容
影响因子：
4.9
作者：
Ascaso, JF;Sales, J;Carmena, R
通讯作者：
Carmena, R
影响因子：
2.1
作者：
Maki, Kevin C.;Fulgoni, Victor L., III;Rubin, Martyn R.
通讯作者：
Rubin, Martyn R.
影响因子：
5.8
作者：
Karakas, Mahir;Thorand, Barbara;Herder, Christian
通讯作者：
Herder, Christian
影响因子：
16.2
作者：
Ford, ES;Ajani, UA;Liu, S
通讯作者：
Liu, S
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad