Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis.
Ran GTPase, an eukaryotic gene novelty, is involved in amphioxus mitosis.
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DOI：
10.1371/journal.pone.0196930
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
D'Aniello S
中科院分区：
文献类型：
--
作者：
Coppola U;Caccavale F;Scelzo M;Holland ND;Ristoratore F;D'Aniello S
Ran （RAS相关核蛋白）是一个小的GTPase，属于RAS超家族，专门从事核运输。Ran通过不同的辅助蛋白在核进出口、有丝分裂进程和纺锤体组装等过程中发挥关键作用。因此，Ran功能障碍与几种人类病理有关。这项工作说明了Ran同源物在进化过程中的高度氨基酸保守性，反映在其在核运输中的保守作用。此外，我们研究了Ran和Stx在后生动物前遗传连锁的进化情景，并假设这两个基因在后生动物间的染色体接近可能与调控逻辑或功能连锁有关。我们首次研究了文昌鱼发育过程中Ran的表达，并报道了其存在于神经囊泡、口腔、鳃缝和肠道中，这些区域与参与活跃细胞分裂的身体区域相对应。
Ran (ras-related nuclear protein) is a small GTPase belonging to the RAS superfamily that is specialized in nuclear trafficking. Through different accessory proteins, Ran plays key roles in several processes including nuclear import-export, mitotic progression and spindle assembly. Consequently, Ran dysfunction has been linked to several human pathologies. This work illustrates the high degree of amino acid conservation of Ran orthologues across evolution, reflected in its conserved role in nuclear trafficking. Moreover, we studied the evolutionary scenario of the pre-metazoan genetic linkage between Ran and Stx, and we hypothesized that chromosomal proximity of these two genes across metazoans could be related to a regulatory logic or a functional linkage. We studied, for the first time, Ran expression during amphioxus development and reported its presence in the neural vesicle, mouth, gill slits and gut corresponding to body regions involved in active cell division.
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影响因子：
4.6
作者：
Annona G;Caccavale F;Pascual-Anaya J;Kuratani S;De Luca P;Palumbo A;D'Aniello S
通讯作者：
D'Aniello S
影响因子：
64.5
作者：
BENNETT, MK;GARCIAARRARAS, JE;SCHELLER, RH
通讯作者：
SCHELLER, RH
影响因子：
2.9
作者：
Holland, ND;Holland, LZ
通讯作者：
Holland, LZ
影响因子：
4.8
作者：
Hsiao, PW;Lin, DL;Chang, C
通讯作者：
Chang, C
DOI：
10.1002/jez.b.21179
发表时间：
2007-07-15
影响因子：
2.2
作者：
Fuentes, Michael;Benito, Elia;Escriva, Hector
通讯作者：
Escriva, Hector