The effectiveness of incentives for research participation: A systematic review and meta-analysis of randomized controlled trials.
The effectiveness of incentives for research participation: A systematic review and meta-analysis of randomized controlled trials.
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DOI：
10.1371/journal.pone.0267534
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
招募在进行随机对照试验（RCT）中发挥着至关重要的作用。适当招募的挑战和失败导致试验提前终止。有人建议将货币激励作为应对这些挑战的潜在解决方案。因此，我们的目的是进行系统的回顾和分析，以评估激励措施对愿意同意和参与随机对照试验的参与者数量的影响。使用以下关键词对电子数据库进行了系统检索，从开始到 2021 年 9 月 23 日：支付、激励、响应、参与、登记、随机化、随机化和随机对照试验。 Cochrane 偏倚风险工具用于评估纳入试验的质量。风险比 (RR) 是用其相应的 95% 置信区间 (CI) 计算的。所有分析均采用随机效应模型进行。我们使用 Revman 软件进行分析。涉及 6,253 名参与者的 6 项随机对照试验符合纳入标准。我们的分析显示，当向参与者提供奖励时，响应率（RR：1.27；95％CI：1.04，1.55；P = 0.02）和同意率（RR：1.44；95％CI：1.11，1.85；P = 0.006）显着提高。即使是少量的激励也能显着提高同意率（RR：1.33；95% CI：1.03，1.73；P = 0.03）和应答率（RR：1.26；95% CI：1.08，1.47；P = 0.004）。总之，我们的荟萃分析表明，即使提供很小的货币价值激励，参与者的同意率和回应率也会显着增加。这些发现表明，激励措施可用于降低招募失败率和随后的研究终止率。然而，需要进一步的随机对照试验来确定一个关键阈值，超过该阈值奖励金额不会进一步改变答复率，以及财务奖励可能有效的随机对照试验类型。
Recruitment plays a vital role in conducting randomized control trials (RCTs). Challenges and failure of proper recruitment lead to early termination of trials. Monetary incentives have been suggested as a potential solution to these challenges. Therefore, we aimed to do a systematic review and analysis to evaluate the effect of incentives on the number of participants willing to consent to and participate in RCTs. Electronic databases were systematically searched from inception to September 23rd, 2021, using the following keywords: payments, incentive, response, participation, enrollment, randomized, randomization, and RCT. The Cochrane Risk of Bias tool was used to assess the quality of the included trials. Risk ratios (RRs) were calculated with their corresponding 95% confidence interval (CI). All analyses were done with the random-effects model. We used Revman software to perform the analysis. Six RCTs with 6,253 Participants met the inclusion criteria. Our analysis showed significant improvement in response rate (RR: 1.27; 95% CI: 1.04, 1.55; P = 0.02) and consent rates (RR: 1.44; 95% CI: 1.11, 1.85; P = 0.006) when an incentive payment was offered to participants. Even a small amount of incentive showed significant improvement in both consent (RR: 1.33; 95% CI: 1.03, 1.73; P = 0.03) and response rates (RR: 1.26; 95% CI: 1.08, 1.47; P = 0.004). In conclusion, our meta-analysis demonstrated statistically significant increases in the rate of consent and responses from participants when offered even small monetary value incentives. These findings suggest that incentives may be used to reduce the rate of recruitment failure and subsequent study termination. However, further RCTs are needed to establish a critical threshold beyond which incentive amount does not alter response rates further and the types of RCTs in which financial incentives are likely to be effective.
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影响因子：
3.7
作者：
Page MJ;McKenzie JE;Bossuyt PM;Boutron I;Hoffmann TC;Mulrow CD;Shamseer L;Tetzlaff JM;Akl EA;Brennan SE;Chou R;Glanville J;Grimshaw JM;Hróbjartsson A;Lalu MM;Li T;Loder EW;Mayo-Wilson E;McDonald S;McGuinness LA;Stewart LA;Thomas J;Tricco AC;Welch VA;Whiting P;Moher D
通讯作者：
Moher D
影响因子：
2.2
作者：
Wilkinson, M;Moore, A
通讯作者：
Moore, A
影响因子：
2.9
作者：
Treweek S;Lockhart P;Pitkethly M;Cook JA;Kjeldstrøm M;Johansen M;Taskila TK;Sullivan FM;Wilson S;Jackson C;Jones R;Mitchell ED
通讯作者：
Mitchell ED
影响因子：
2.5
作者：
Jennings, Claudine G.;MacDonald, Thomas M.;Mackenzie, Isla S.
通讯作者：
Mackenzie, Isla S.
影响因子：
2.7
作者：
Free, Caroline;Hoile, Elizabeth;Knight, Rosemary
通讯作者：
Knight, Rosemary