Genetic testing in psychiatry: a review of attitudes and beliefs.
Genetic testing in psychiatry: a review of attitudes and beliefs.
复制标题
DOI：
10.1521/psyc.2011.74.4.315
复制
发表时间：
2011
期刊：
影响因子：
2.4
通讯作者：
Appelbaum PS
中科院分区：
文献类型：
--
作者：
Lawrence RE;Appelbaum PS
精神疾病基因检测的出现提出了关于何时以及如何使用这些检测的难题。关于这些问题的政策的制定可以通过各种方式了解关键利益相关者的观点：患者，家庭成员，医疗保健专业人员和公众。在这里，我们回顾这些群体对基因检测的态度的实证研究。患者和家庭成员对诊断性和预测性基因检测表现出强烈的兴趣，在相当大的程度上，精神科医生也分享了他们的热情。产前检查的利用似乎可能取决于父母对堕胎的看法和疾病的严重程度。父母对儿童的预测性测试表现出惊人的兴趣，即使在没有预防性干预措施的情况下。许多人报告说，他们准备根据检查结果改变自己的生活方式和婚姻与家庭计划。受访者还担心负面后果，从歧视到无法科普其“基因命运”的知识。对基因检测信念的实证研究表明，检测可能会被广泛接受，但这些研究存在方法学上的局限性，降低了结论的确定性，并表明需要用更具代表性的样本进行进一步研究。
The advent of genetic testing for psychiatric conditions raises difficult questions about when and how the tests should be used. Development of policies regarding these issues may be informed in a variety of ways by the views of key stakeholders: patients, family members, healthcare professionals, and the general public. Here we review empirical studies of attitudes towards genetic testing among these groups. Patients and family members show strong interest in diagnostic and predictive genetic testing, and to a considerable extent psychiatrists share their enthusiasm. Prenatal test utilization seems likely to depend both on parental views on abortion and the seriousness of the disorder. Parents show a surprising degree of interest in predictive testing of children, even when there are no preventive interventions available. Many persons report themselves ready to alter their lifestyles and plans for marriage and family in response to test results. Respondents also fear negative consequences, from discrimination to being unable to cope with knowledge of their “genetic fate.” Empirical studies of beliefs about genetic testing suggest tests are likely to be embraced widely, but the studies have methodologic limitations, reducing the certainty of their conclusions, and indicating a need for further research with more representative samples.
登录
查看更多内容
DOI：
10.1089/gte.2007.0100
发表时间：
2008-06-01
期刊：
GENETIC TESTING
影响因子：
--
作者：
Meiser, Bettina;Kasparian, Nadine A.;Schofield, Peter R.
通讯作者：
Schofield, Peter R.
影响因子：
158.5
作者：
Green, Robert C.;Roberts, J. Scott;Farrer, Lindsay A.
通讯作者：
Farrer, Lindsay A.
影响因子：
4.5
作者：
Corcoran, C;Malaspina, D;Hercher, L
通讯作者：
Hercher, L
影响因子：
1.4
作者：
Laegsgaard, Mett Marri;Kristensen, Ann Suhl;Mors, Ole
通讯作者：
Mors, Ole
DOI：
10.1002/ajmg.b.30609
发表时间：
2008-04-05
影响因子：
2.8
作者：
Laegsgaard, Mett Marri;Mors, Ole
通讯作者：
Mors, Ole