Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis.
Gray matter blood-brain barrier water exchange dynamics are reduced in progressive multiple sclerosis.
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DOI：
10.1111/jon.12912
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发表时间：
2021-11
影响因子：
2.4
通讯作者：
Rooney, William D.
中科院分区：
文献类型：
--
作者：
Tagge, Ian J.;Anderson, Valerie C.;Springer, Charles S.;Sammi, Manoj K.;Bourdette, Dennis M.;Spain, Rebecca, I;Rooney, William D.
目的：比较进展型多发性硬化(PMS)患者和健康对照组(HC)T2脑白质(WM)病变和正常白质和灰质(NAWM和NAGM)的跨毛细血管壁水交换。动态增强的7T MRI数据来自19名HC和23名PMS受试者。通过快门速度(SS)范例建模，创建代表组织微血管和微结构特性的高分辨率药代动力学参数图，以获得血液体积分数(Vb)、水分子毛细血管外流速率常数(Kpo)和水毛细血管壁通透性表面积乘积(Pws、≡、Vb*kpo)的估计值。用线性回归模型分析两组间的kpo和P w S的差异，以及PMS患者西药皮损与NAWM皮损之间的差异。制作了高分辨率参数图，以可视化组织类型并解决个别WM病变。经前综合征患者的正常灰质kpo和P w S明显低于正常对照组(p≤.01)。分析了10例经前综合征患者的21个T2 WM病变。与PMS NAWM相比，西医皮损的Kpo显著降低(p<；.0001)。与HC相比，PMS NAGM的跨毛细血管水交换减少，在PMS WM病变中进一步减少，提示病理上大脑代谢受损。Kpo提供了脑代谢活动和/或偶联的灵敏测量，并且可以比评估代谢活动的传统成像技术以更高的空间分辨率进行标测。
To compare transcapillary wall water exchange, a putative marker of cerebral metabolic health, in brain T2 white matter (WM) lesions and normal appearing white and gray matter (NAWM and NAGM, respectively) in individuals with progressive multiple sclerosis (PMS) and healthy controls (HC). Dynamic‐contrast‐enhanced 7T MRI data were obtained from 19 HC and 23 PMS participants. High‐resolution pharmacokinetic parametric maps representing tissue microvascular and microstructural properties were created by shutter‐speed (SS) paradigm modeling to obtain estimates of blood volume fraction (vb), water molecule capillary efflux rate constant (k po), and the water capillary wall permeability surface area product (PwS ≡ vb*kpo ). Linear regression models were used to investigate differences in (i) k po and P w S between groups in NAWM and NAGM, and (ii) between WM lesions and NAWM in PMS. High‐resolution parametric maps were produced to visualize tissue classes and resolve individual WM lesions. Normal‐appearing gray matter k po and P w S were significantly decreased in PMS compared to HC (p ≤ .01). Twenty‐one T2 WM lesions were analyzed in 10 participants with PMS. k po was significantly decreased in WM lesions compared to PMS NAWM (p < .0001). Transcapillary water exchange is reduced in PMS NAGM compared to HC and is further reduced in PMS WM lesions, suggesting pathologically impaired brain metabolism. k po provides a sensitive measure of cerebral metabolic activity and/or coupling, and can be mapped at higher spatial resolution than conventional imaging techniques assessing metabolic activity.
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影响因子：
3.3
作者：
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通讯作者：
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