Long non-coding RNAs in the regulation of the immune response.
Long non-coding RNAs in the regulation of the immune response.
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DOI：
10.1016/j.it.2014.07.005
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发表时间：
2014-09
影响因子：
16.8
通讯作者：
Lindsay MA
中科院分区：
文献类型：
--
作者：
Heward JA;Lindsay MA
lncRNA表达的广泛变化与免疫反应有关。lncrna调节先天免疫激活后的炎症反应。lncrna调控T细胞的分化和迁移。长链非编码rna的作用是通过多种机制介导的。越来越清楚的是，长链非编码rna （lncRNAs）通过多种不同的机制调节多种生物反应。在免疫学领域，最近的出版物表明，在先天免疫反应和T细胞发育、分化和激活的激活过程中，lncrna的表达发生了广泛的变化。这些lncrna通过调节蛋白-蛋白相互作用或通过其与RNA和DNA的碱基对能力控制免疫的重要方面，如炎症介质的产生、分化和细胞迁移。我们回顾了目前对这些免疫相关lncRNA的作用机制的理解，讨论了它们对生理和病理过程的影响，并强调了免疫学和lncRNA生物学交叉研究的重要领域。
Widespread changes in lncRNA expresssion are associated with the immune response. lncRNAs regulate the inflammatory response following activation of innate immunity. lncRNAs regulate T cell differentiation and migration. The action of long non-coding RNAs is mediated via diverse mechanisms. It is increasingly clear that long non-coding RNAs (lncRNAs) regulate a variety biological responses, and that they do so by a diverse range of mechanisms. In the field of immunology, recent publications have shown widespread changes in the expression of lncRNAs during the activation of the innate immune response and T cell development, differentiation, and activation. These lncRNAs control important aspects of immunity such as production of inflammatory mediators, differentiation, and cell migration through regulating protein–protein interactions or via their ability to basepair with RNA and DNA. We review the current understanding of the mechanism of action of these immune-related lncRNAs, discuss their impact on physiological and pathological processes, and highlight important areas of inquiry at the intersection between immunology and lncRNA biology.
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影响因子：
64.5
作者：
Gomez JA;Wapinski OL;Yang YW;Bureau JF;Gopinath S;Monack DM;Chang HY;Brahic M;Kirkegaard K
通讯作者：
Kirkegaard K
影响因子：
30.5
作者：
通讯作者：
--
DOI：
10.1073/pnas.1324151111
发表时间：
2014-05-20
影响因子：
11.1
作者：
Hsieh, Chen-Lin;Fei, Teng;Kantoff, Philip W.
通讯作者：
Kantoff, Philip W.
DOI：
10.1126/science.1240925
发表时间：
2013-08-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Carpenter S;Aiello D;Atianand MK;Ricci EP;Gandhi P;Hall LL;Byron M;Monks B;Henry-Bezy M;Lawrence JB;O'Neill LA;Moore MJ;Caffrey DR;Fitzgerald KA
通讯作者：
Fitzgerald KA
影响因子：
10.5
作者：
Cabili, Moran N.;Trapnell, Cole;Rinn, John L.
通讯作者：
Rinn, John L.